ID G5BW11_HETGA Unreviewed; 1503 AA.
AC G5BW11;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Transcription initiation factor TFIID subunit 1 {ECO:0000256|ARBA:ARBA00040102};
GN ORFNames=GW7_12838 {ECO:0000313|EMBL:EHB13472.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13472.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB13472.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF1 family.
CC {ECO:0000256|ARBA:ARBA00009064}.
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DR EMBL; JH172118; EHB13472.1; -; Genomic_DNA.
DR STRING; 10181.G5BW11; -.
DR InParanoid; G5BW11; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; IEA:InterPro.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05511; Bromo_TFIID; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 1.10.1100.10; TAFII-230 TBP-binding domain; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR040240; TAF1.
DR InterPro; IPR022591; TAF1_HAT_dom.
DR InterPro; IPR009067; TAF_II_230-bd.
DR InterPro; IPR036741; TAFII-230_TBP-bd_sf.
DR InterPro; IPR041670; Znf-CCHC_6.
DR PANTHER; PTHR13900; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR PANTHER; PTHR13900:SF0; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR Pfam; PF12157; DUF3591; 1.
DR Pfam; PF09247; TBP-binding; 1.
DR Pfam; PF15288; zf-CCHC_6; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR SUPFAM; SSF47055; TAF(II)230 TBP-binding fragment; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000313|EMBL:EHB13472.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein biosynthesis {ECO:0000313|EMBL:EHB13472.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1482..1501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1295..1365
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1418..1488
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 177..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1372..1399
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 178..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1503 AA; 171949 MW; F6ACB6916E031A55 CRC64;
MSETDSDEDS AGGGPFSLTG FLFGNINGAG QLEGESVLDD ECKKHLAGLG ALGLGSLITE
LTANEELTGT DGALVNDKGW IRSTEDAVDY SDINEVAEDE SRRYQQTMGS MQPLCHTDYD
EDDYDADCED IDCKLMPPPP PPPGPIKKDK DQDAITGVSE DGEGIILPSI IAPSSLASEK
VDFSSSSDSE SEMGPQEATQ TESEDGKLTL PLAGIMQHDA TKLLPSVTEL FPEFRPGKVL
RFLRLFGPGK NVPSVWRSAR RKRKKKHREL MQEEQVQEVE CSVDSEVNQK SLWNYDYAPP
PPPEQCLSDD EITMMAPVES KFSQLTGDTD KVTDTKPRVA EWRYGPARLW YDMLGVPEDG
SGFDYGFKLR KTEHEPVVKC RMMEEYKKLE ESNGTDLLAD ENFLMVTQLH WEDDIIWDGE
DVKHKGTKPQ RASLAGWLPS SMTRNAMAYN VQQEIPDEKE EATSNSPSKE SKKESSLKKS
RILLGKTGVI KEEPQQNMSQ PVVKDPWNLS NDEYYYPKQQ GLRGTFGGNI IQVQTASFLW
ELRQPFFPTH MGPIKLRQFH RPPLKKYSFG ALSQPGPHSV QPLLKHIKKK AKMREQERQA
SGGGEMFFMR TPQDLTGKDG DLILAEYSEE NGPLMMQVGM ATKIKNYYKR KPGKDPGAPD
CKYGETVYCH TSPFLGSLHP GQLLQAFENN LFRAPRFLYV IFILAPIYLH KMPETDFLII
RTRQGYYIRE LVDIFVVGQQ CPLFEVPGPN SKRANTHIRD FLQKKAFPSH SESSIRKRLK
LCADFKRTGT DSNWWVLKSD FRLPTEEEIR AMVSPEQCCA YYSMIAAEQR LKDAGYGEKS
FFAPEEENEE DFQMKIDDEV RTAPWNTTRA FIAAMKGKCL LEVTGVADPT GCGEGFSYVK
IPNKPTQQKD DKEPQPVKKT VTGTDADLRR LSLKNAKQLL RKFGVPEQEI KKLSRWEVID
MIRTMSTEQA RSGEGPMSKF ARGSRFSVAE HQERYKEECQ RIFDLQNKVL SSTEVLSTDT
DSSSAEDSDF EEMGKNIENM LQNKKTSSQL SREREEQERK ELQRMLLDLS HISRKEYVRC
ETVRKPAVID AYVRIRTTKD EEFIRKFALF DEQHREEMRK ERRRIQEQLR RLKRNQEKEK
LKGPPEKKPK KMKERPDLKL KCGACGAIGH MRTNKFCPLY YQTNAPPSNP VAMTEEQEEE
LEKTVIHNDN EELIKVEGTK IVLGKQLIES AAEVRRKSLV LKFPKQRLPP EKKRRVGTTV
HCDYLNRPHK SIHRRQTDPT VTLSSILESV ISDMRDLPNT YPFHTPVNAK VVKDYYKIIT
RPMDLQTLRE NVRKRLYPSR EEFREHLELI VKNSATYNGP KHSLTQISQS MLDLCDEKLK
EKEDKLARLE KAINPLLDDD DQVAFSFILD NIVTQKMMAV PDSWPFHHPV NKKFVPDYYK
VIINPMDLET IRKNISKHKY QSRESFLDDV NLILANSVKY NGGYFFFFSL SILHALLVTI
IKI
//
