ID G5BY08_HETGA Unreviewed; 561 AA.
AC G5BY08;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=CHST15 {ECO:0000313|EMBL:JAN99639.1};
GN ORFNames=GW7_18042 {ECO:0000313|EMBL:EHB14169.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14169.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14169.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN99639.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:JAN99639.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; JH172435; EHB14169.1; -; Genomic_DNA.
DR EMBL; GEBF01003993; JAN99639.1; -; Transcribed_RNA.
DR RefSeq; XP_004838817.1; XM_004838760.2.
DR RefSeq; XP_012925428.1; XM_013069974.1.
DR RefSeq; XP_012925429.1; XM_013069975.1.
DR RefSeq; XP_012925430.1; XM_013069976.1.
DR AlphaFoldDB; G5BY08; -.
DR STRING; 10181.G5BY08; -.
DR GeneID; 101726691; -.
DR KEGG; hgl:101726691; -.
DR CTD; 51363; -.
DR eggNOG; ENOG502QU6N; Eukaryota.
DR InParanoid; G5BY08; -.
DR OMA; HVDSKQM; -.
DR OrthoDB; 3939141at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000010199; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050656; F:3'-phosphoadenosine 5'-phosphosulfate binding; IEA:Ensembl.
DR GO; GO:0050659; F:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; IEA:Ensembl.
DR GO; GO:0019319; P:hexose biosynthetic process; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR15723; CARBOHYDRATE SULFOTRANSFERASE 15; 1.
DR PANTHER; PTHR15723:SF0; CARBOHYDRATE SULFOTRANSFERASE 15; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000256|RuleBase:RU361155, ECO:0000313|EMBL:EHB14169.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 254..511
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 561 AA; 65140 MW; 4C4ECDAB17238E63 CRC64;
MRHCINCCIH LIPDNAHKQK VGCRGGLQHS QQVCPTCRGE NKILFRVDSK QMNLLAVLEV
RTEGNENWGG FLRFKKGKRC SLIFGLIIMT LVMASYILSG AHQELLISSP FHYGSFPNNP
SLMDGENPSD MKEHHYQPSV NNISYMKDYP SIKLIINSIT ARIEFTTRKL PVLQDLKRQE
LHMFSVIPNK FLPNSKSPCW YEEFSGRNTT DPYLTNSYVL YSKRFRSTFD TLRKAFWGHL
SHVHGKHFRL RCLPHFYIIG QPKCGTTDLY DRLRLHPEVK FSAIKEPHWW TRKRFGIVRL
RDGLRDRYPV EDYLDLFDLA AHQIHQGLQA SSAKEQGKMN QIIIGEASAS TMWDNNAWTF
FYDNSTDGEP PFLTQDFIHA FQPDAKLIVM LRDPVERLYS DYLYFASSNK SADDFHEKVT
EALQLFENCM LDYSLRACVY NNTLNNAMPV RLQVGLYAVY LLDWLTVFNK EQFLILRLED
HASNVKYTMH RVFHFLNLGP LSEKQEALMT KSPASNVRRP EDRNLGPMWP VTQKILRDFY
GPFNARLAQV LADEAFAWKA P
//
