ID G5BY32_HETGA Unreviewed; 2194 AA.
AC G5BY32;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Putative G-protein coupled receptor 179 {ECO:0000313|EMBL:EHB14193.1};
GN ORFNames=GW7_00456 {ECO:0000313|EMBL:EHB14193.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14193.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14193.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; JH172436; EHB14193.1; -; Genomic_DNA.
DR STRING; 10181.G5BY32; -.
DR eggNOG; KOG4418; Eukaryota.
DR InParanoid; G5BY32; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF7; G-PROTEIN COUPLED RECEPTOR 179-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EHB14193.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2194
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474996"
FT TRANSMEM 378..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 426..632
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 735..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1207..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1571..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1892..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1937..1973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2110..2194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1790..1813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1831..1872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2194 AA; 235476 MW; 0E880A5649AB84F8 CRC64;
MGTGATVQPS GPWVLLGCCL LCAWALGDLR PLRSLPLLPS QTEPGSVPER IPPQGAEGAL
AFLYSGDPQQ LLRANCSKHY EVPGAEARPG LPPVLQRAAG TLAQAANFLN MLLQANDIRE
ASVEEDVEWY QALVRSVAEG DPRAYRALLT FHPPPGASHL QLALQATRMG VETLLQELAG
SRVWGESPAE DLDSPALHKR VLTNDLQSLN SPKWPQGDGY VGDMQQVRLS HPFLDCQEGR
LRPGWLVTLS ATFYGLKPDL SPEVRGQVQM DVDLQRVDIN QCADGPGWFS NTHLCDLNST
QCVPLEGRGF VLDQYLCRCR PGFFGASGSG GLEEDASQTP GQFGSPQDNT GWLLRCQPCP
EGCPSCMDAT PCLVQEALAL RAVVLACQAC CMLAVFLSML VSYQCRWNKA SRAPPHSLHV
VLLEAILFGS LLLYFPVFIL YFKPSVFRCI TLRWVRLLGF AIVYGTIILK LYRVLQLFLS
RAAQRSAPLG SGRLLRHLGL LLLVVLGFLA VWTAGVLERG QFAPLVTQGH TAAGRHFHLC
HHDRSDYIMV GVEVLLLCWG SFLSCATREV PSAFHELRYM GLALHNELLL SAAFHMARFM
LVPSLHPDWT LLLFFFHTHS TVTTTLALIF FPMFQRPGAP PHEEILDEAY EDELGLQRLG
SYLDSSVASA WSEHSLDPGD IRDELKKLYA QLEVRKTKEM AANNPHLPNK WGSSRHGLGR
SFLRYLAEFP EALARQHSRD SGSPGRSSLP SSSCRRLLSS SHQDTPEGGP ALCQSHCTYD
QHHPEQELPL LGSVLRRNLS RKALRLEGQE PAKGPPALGF RSASAHNLMG GEQLSRAWPS
SLQKSLSDMA GRREKALLVA SQTYLEETYW QAKERQEQKK AEAATARPVW RPSARRLERA
WSPPLSAPPS PAKNSSMDSS LASRRLQEEG GRRLPHPPIH HQVSSPILVL SGACPAEQRM
LSPSSTLAPV PTPALAPVSG PPQSPILLTY ICPWENAELP VKKETVVQEG ALGSHSPALA
RGKLWRPLSE AVGKRVAMDS EMDAEAGRPE GEADDRAEDR PKTFSKSHSL KTPVQQGSMR
SLGLAIKALT RSRSTYREKD GGGEVGPDRE KDRAAGAAMA VLPRSPRLGR PKVVSKQAAL
VPCNDEESLQ NQQNAHTSGM LHVCHQDGGR EQEAGGRKLS QGPGESKVEK AGKRGLATLW
QVFGDKSAEQ AKEGPGGRRE PPRSGLLLLG SADRGVAEAC PWEVIKSDTG GLDSSNKAQI
CPWEVSKGAL QRTASGQHRG DSQEDRGTAT GKPEPRGAAV TARRKPERLV RSQEASCPWE
GADPGAVGRS SAAGSVDRRQ AEKPWAEAPG TEAGSPHPAR AELYPWEVGE ADQGTRAPGE
RAAPQAGQSA SKKAAFWREQ EQGADPEPLC PWESTGFRDP SGSLGSSIAE VCPWEVADAP
VPRKAEVCPW KVKEGTEDGT PGQTAKGGDS QKAKEKMPGK AGIQDVTSRE KPEVQIPKQE
AVCPWESVGS GSLPPLPGPQ EPERSRVISQ RLGSAGSGAA EVCPWEVEDT PTDGKAQICP
WEVGAGAGQE RAWGPEGIRS PNATGKTRPG RPAMEGEWAH PWETSGPGGS WQHKDTLDTE
GPRAGLQDQG RLGCRPADMC PWEAQEAPTS DKAKICSWEE NEGAPGKGLG QELGNQETLE
KGRFPLPAGG VAEWEAKLHQ EQEAVCPWED QDLREWSAPV PKASDLSWEV SAEGTQKGEL
KQDPKTGSFP EHETQGKAPA SKAESMTEAG GGTSKAGLSV CPWDTMAPEG SLSHPNSQHP
DQMEASSQAL GSGGGSIARM CPWDAPDPDV CEAESSAKAE LCPREATEKV LERGAWRQDG
KGDSREGTGR AQERPEPQQV QETPEMADCR KLGATCPRDS RDGGGVAPQL APCASEGRRA
RAKAAGHMGA GAAEVCPWEV EEKPSTQEAE VSPREPGPGG AGEGTPAQGV AGGFQGQGEV
LFLKAGSAGA EGDFAAAAVT LGREQDIVGP WDGTGSEGPV PQGDALGADC YKVSRCGAGS
GGTRTAELCQ WEVTDPEGNK IRGTMADVCP WEDTSAPLEE PGFRALTVAQ TENVPKAAEK
SLCFSVSFIP ESKSSHPKGV KGAKAARSAG SQEGGRALGG PSGLGPRTRV SLELSVQGAE
APKSSSLAED HGQVASEAQD EYLSPPPAYP WDFE
//
