ID G5BYB1_HETGA Unreviewed; 841 AA.
AC G5BYB1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament 3 {ECO:0000256|ARBA:ARBA00033124};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
GN ORFNames=GW7_07637 {ECO:0000313|EMBL:EHB14272.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14272.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14272.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH172442; EHB14272.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BYB1; -.
DR STRING; 10181.G5BYB1; -.
DR eggNOG; KOG1216; Eukaryota.
DR InParanoid; G5BYB1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 2.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 110..394
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..253
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 305..365
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..555
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 95037 MW; ABA21C855274F9E2 CRC64;
MGEGMGGKGR WRWGREGGEG EKRRESWKEK VPAEEAWGEG RASGTKERQK QAGEEGPKGE
EVAARKRQRS ALAPRLAYSS AESSLDFSQS SSLLNGGSGG GDYKLSRSNE KEQLQGLNDR
FAGYIEKVHF LEQQNKEIEA EIQALRQKQA SHAQLGDAYD QEIRELRATL ELVNHEKAQV
QLDSDHLEED IHRLKERFEE EARLRDDTEV AIRALRKDIE ESSLVKVELD KKVQSLQDEV
AFLRSNHEEE VADLLAQIQA SHITVERRDY LKTDISTALK EIRSQLECHS DQNMHQAEEW
FKCRYAKLTE AAEQNKEAIR SAKEEIAEYR RQLQSKSIEL ESDTIQQLEN ELRGTKWEMA
RHLREYQDLL NVKMALDIEI AAYRKLLEGE ETRFSTFSGS ITGPIYTHRQ PSVTISSKIQ
KTKVEAPKLK VQHKFVEEII EETKVEDEKS EMEDALTAIA EELAVSSKEE AEEKEEEQKA
EEEVVAAKKS PVKAAALEVK EEEEEEKEEE EGQEEEEEED EGAKSDQAEE GGSEKEGSSE
KDEAEQEEEG EAEAEGEEEA KAKKEKKVGE KREEVAAKEE LVTEAKVGKP EKAKSPVPKS
PVEEVKLKAE AVAGKSEQKE KEKVEEEKKE VTKEAPKEEK VEKKEEKPKD VPEKKAESPV
KEKAVKEVVP KPVKVGAEKE AKEEEKPQQW EEKEKEKEKA EEEGGSEEGS DQGSKESRKE
DIAVNGEVEG KEEEEEEKQE TKEKGSGREE EKGVVTNGLD VSPADEKKGG DRSDEKVVVT
KMVEKITSEG GDGATKYITK SVTVTQKVEE HEETFEEKLV STKKVEKVTS HAIVKEVTQN
D
//
