ID   G5BZQ1_HETGA            Unreviewed;       481 AA.
AC   G5BZQ1;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   Flags: Fragment;
GN   ORFNames=GW7_10448 {ECO:0000313|EMBL:EHB14762.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14762.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB14762.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC         glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00000251,
CC         ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; JH172612; EHB14762.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5BZQ1; -.
DR   STRING; 10181.G5BZQ1; -.
DR   eggNOG; ENOG502QTUU; Eukaryota.
DR   InParanoid; G5BZQ1; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; HYALURONIDASE; 1.
DR   PANTHER; PTHR11769:SF7; HYALURONIDASE-4; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   PRINTS; PR00848; SPERMPH20.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   ACT_SITE        147
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
FT   CARBOHYD        368
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-2"
FT   DISULFID        59..351
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT   DISULFID        223..237
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT   DISULFID        376..387
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT   DISULFID        381..435
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT   DISULFID        437..446
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EHB14762.1"
SQ   SEQUENCE   481 AA;  55023 MW;  025E82BCC3D0DF3C CRC64;
     MKLSPEGQFR LCIIQSIHLT SWLLIFLNLN SVCSLKPAQL PMYQRKPFIA AWNTPTDQCL
     KKYNVTLNLQ MFQVTGSTLS KARGQNVTIF YPNRLGYYPW YTSHGVPING GLPQNISLEV
     HLKKAGQDID YYIPAKDFSG LAIIDWEYWR PQWTRNWNAK DVYRRKSKEL ISDMQRNVKS
     TDIEYLAKAT FEESAKEFMM KTIKLGIKKR PKGLWGYYLY PDCHNYNMNE PNYTGSCPEE
     AVLKNNELSW LWNSSAALYP SIAIKKSFRD HETVLHFSKF RVQESMRIST MTSHEYALPV
     FVYTRLGYRD DPLFFLSRQD LINTIGESAA LGAAGIVIWG DMNLTSSEEN CTKVNQFLSS
     DFGSYIVNMS TAAEVCSLYL CRNNGRCIRK TWNASDYLYL NNESYHIEIS EDGEFSVKGN
     VTDADLAMMK EKFFCHCYQG YEGADCREIK EADGSAGLSS CSGSPMTLCL LSLASYQNIQ
     V
//