ID G5BZU7_HETGA Unreviewed; 470 AA.
AC G5BZU7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Transmembrane prolyl 4-hydroxylase {ECO:0000313|EMBL:EHB14789.1};
DE Flags: Fragment;
GN ORFNames=GW7_19902 {ECO:0000313|EMBL:EHB14789.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14789.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14789.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
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DR EMBL; JH172617; EHB14789.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BZU7; -.
DR STRING; 10181.G5BZU7; -.
DR eggNOG; KOG1591; Eukaryota.
DR InParanoid; G5BZU7; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10869:SF230; TRANSMEMBRANE PROLYL 4-HYDROXYLASE; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EHB14789.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 274..428
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB14789.1"
SQ SEQUENCE 470 AA; 53393 MW; B0C83A7CB94A3DAB CRC64;
RPGDDEDSTV QPLCKPRGIC SRAYFLVLMV FVHLYLGNVL ALLLFVHYSN GDESTEPGPP
RRSPGPLTVP TLGPLTRLEG IKVGYERKVQ LVTGKDHVIR TLSLKPLLFE IPGFLSDEEC
RLIIHLAQMK GLQRSQILST EEYEEAMSTV QVSQLDLFQL LDQNHDGLLQ LREVLAQTRL
GNGWWMTPEN IQEMYSAIKA DPNGDGVLSL QEFSNMDLRD FHMYMRSHKG ESSELVRNSH
HTWLYQGEGA HHIMRAIRQR VLHLTRLSPE IVELSEPLQV VRYSEGGHYH AHLDSGPVYP
ETICSHTKLV ANESVPFETS SPLSYSYMTV LFYLNNVTSG GETVFPVADN RTYDEMSLIQ
DDVDLRDTRR HCDKGNLRVK PQQGTAVFWY NYLPDGQGWV GDVDDYSLHG GCLVTRGTKW
IANNWINVDP SRARQALFQQ EMARLSREGG ANSQPEWALD RAYRDARVEL
//
