ID G5C0K9_HETGA Unreviewed; 1157 AA.
AC G5C0K9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Zinc finger protein 516 {ECO:0000313|EMBL:EHB15070.1};
GN ORFNames=GW7_03538 {ECO:0000313|EMBL:EHB15070.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15070.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB15070.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; JH172720; EHB15070.1; -; Genomic_DNA.
DR RefSeq; XP_004861992.1; XM_004861935.2.
DR RefSeq; XP_004861993.1; XM_004861936.2.
DR RefSeq; XP_004861994.1; XM_004861937.2.
DR RefSeq; XP_004861995.1; XM_004861938.2.
DR AlphaFoldDB; G5C0K9; -.
DR STRING; 10181.G5C0K9; -.
DR Ensembl; ENSHGLT00100008848; ENSHGLP00100008746; ENSHGLG00100006510.
DR GeneID; 101703915; -.
DR KEGG; hgl:101703915; -.
DR CTD; 9658; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; G5C0K9; -.
DR OMA; YQGWGVG; -.
DR OrthoDB; 3849084at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF3; ZINC FINGER PROTEIN 516; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 34..61
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 62..84
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 235..262
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 263..290
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 322..349
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 503..530
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1092..1115
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 124641 MW; 02DBC6C4778F3DE7 CRC64;
MDRNREAEMD LRRGPSPPRA SRSQETDGDK AACHSCCICG KSFPFQSSLS QHMRKHTGEK
PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPETSEA QLGEMRVSEG LDGCASPTKS
TSACNRILNG AAQVDSSKIL LRSSRKEAGG AANTAEGEAA TQCSFCKSQF ERKKDLELHV
HQAHKPFKCR LCSYMTLREE SLLSHIERDH ITAQVPNGGE ACVENGKPEL SPGEFPCEVC
GQAFSQTWFL KAHMKKHRGS FDHGCHICGR RFKEPWFLKN HMKAHGPKTG SKNRPRSELD
PIATINNVVQ EEVIVAGLSL YEVCTKCGNL FTNLDSLNAH NAVHRKVEAS RTRALAEEAA
TESPLDTKQL FLQCLNLRPS VAGDGSPGGQ AGRRVAELDP VNSYQAWQLA TRGKVAEPAE
YLKYGAWDEA PAGDVAFDKE RREYILVSQE KRKREQDAPA TQGPPRKRAS LPGDPMLPGH
FDPRPAARPS RRAAASAGHG KSSECFECGK IFRTYHQMVL HSRVHRRAQR DRDSDGDRVA
RARCGSLSEG DSASQPSSPG SACATVDSPG SGLADEAADD SGEEPSPEPA PGGQPRRCCS
SEEVASTVLS NGDQSHQLGN NPPRKDTSES KVGIATSVSV LENSSRETSK RPEQRRFSLD
LKMPAFHPTQ EVPSSSDGVD FPSSTEGADL QLTLESQAGH PKDKLSDLHN KEHSGGGKSA
PAPDLVPLDL SARSTRDDSS NKEVATSLQA ALVIHPCPYC NHKTYYPEVL WMHKRIWHRV
SCNSMAPQWI QPNGYKSIRS NLVYLARSGR TGPPPVLGGK ECQPLLLARF TRTQGPGGAP
GPKGISSPLG VTTKAASMPK NKESHSSSPC ALWAPGPDGY RQTKPSQGQE PSSASVQGPP
AKPKLEASSK PAPALGSGSL GRSATPTPSV ITRVGAQPLG SSKPVENFGV PLAGAGFAPP
NKHSAPDSLK AKFSPQPQGQ PSAKGEGSPP LPLREPPSKA VQELRTLATC AAGPRGDPAL
QAQPGMAAAP PVLHSIKQEP VAEGHEKRLD ILNIFKTYIP KDFATLYQGW GVSSPGPEHR
GTLRTQARPG DFICAECGKS FHQPSHLRAH MRAHTVVFEC DGPRGSEVHT ASMDAPKQGR
DHANTGTVQT VPLRKGT
//
