ID G5C163_HETGA Unreviewed; 314 AA.
AC G5C163;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Protein FAM26D {ECO:0000313|EMBL:EHB15274.1};
GN ORFNames=GW7_20800 {ECO:0000313|EMBL:EHB15274.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15274.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB15274.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CALHM family.
CC {ECO:0000256|ARBA:ARBA00008497}.
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DR EMBL; JH172824; EHB15274.1; -; Genomic_DNA.
DR RefSeq; XP_004869123.1; XM_004869066.1.
DR AlphaFoldDB; G5C163; -.
DR STRING; 10181.G5C163; -.
DR Ensembl; ENSHGLT00100006021; ENSHGLP00100005938; ENSHGLG00100004477.
DR GeneID; 101704551; -.
DR KEGG; hgl:101704551; -.
DR CTD; 221301; -.
DR eggNOG; ENOG502RKQ2; Eukaryota.
DR InParanoid; G5C163; -.
DR OMA; FRCPCQV; -.
DR OrthoDB; 2899675at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029569; CALHM.
DR PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR PANTHER; PTHR32261:SF5; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 314 AA; 35505 MW; 0C081077B129F7CC CRC64;
MSQNLSNTVS SLWRSGTFIN SFIAGWTVGG QQLFSSYIFR CPCQVGRNFY YGSVFLVVPA
LVLLVAGYAL RGQMWTFASN YCCSCGPLQQ RISPLEHRLA CLRFFSITGR ALVAPLTWLA
VTLLKGTYYQ CAKSEFTSVD HYSVFDNVTA SKREELLAGL PCDRPSASSD MILVRDEVAL
LHRYQSQMLG WILIILTTTA ILVFCCLARC YSLSTLQHHY WTHHLENERE LFKQAAEEHS
WLLIRQCIKK LFGFVPGSED IQQIRIPSCQ DWKEISAPSL LCMEDATHGL YSSLGDRVVE
DNEEEKLGGI ELKP
//
