ID   G5C1D8_HETGA            Unreviewed;       956 AA.
AC   G5C1D8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=F-box only protein 10 {ECO:0000313|EMBL:EHB15349.1};
GN   ORFNames=GW7_18488 {ECO:0000313|EMBL:EHB15349.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15349.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB15349.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH172831; EHB15349.1; -; Genomic_DNA.
DR   RefSeq; XP_004874638.1; XM_004874581.1.
DR   RefSeq; XP_004874639.1; XM_004874582.1.
DR   AlphaFoldDB; G5C1D8; -.
DR   STRING; 10181.G5C1D8; -.
DR   GeneID; 101703867; -.
DR   CTD; 26267; -.
DR   eggNOG; KOG1777; Eukaryota.
DR   InParanoid; G5C1D8; -.
DR   OMA; CNLIFMP; -.
DR   OrthoDB; 2901654at2759; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   Bgee; ENSHGLG00000002122; Expressed in thyroid gland and 10 other cell types or tissues.
DR   CDD; cd22090; F-box_FBXO10; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 3.
DR   InterPro; IPR039448; Beta_helix.
DR   InterPro; IPR006633; Carb-bd_sugar_hydrolysis-dom.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR007742; NosD_dom.
DR   InterPro; IPR022441; Para_beta_helix_rpt-2.
DR   InterPro; IPR006626; PbH1.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   NCBIfam; TIGR03804; para_beta_helix; 1.
DR   PANTHER; PTHR22990; F-BOX ONLY PROTEIN; 1.
DR   PANTHER; PTHR22990:SF15; F-BOX ONLY PROTEIN 10; 1.
DR   Pfam; PF13229; Beta_helix; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF05048; NosD; 1.
DR   SMART; SM00722; CASH; 3.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00710; PbH1; 17.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF51126; Pectin lyase-like; 4.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..48
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   REGION          313..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   956 AA;  105066 MW;  397BEE112D0FF497 CRC64;
     METGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW
     PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSVCFSL FRRRRERRTL SVGPGHEFDS
     LGSALAMASL YDRIVLFPGV YEEQGEIILK VPVEIVGHGK LGKVTLLASI DQHCSTTRLC
     NLVFMPAWFS PIMYKTTSGH VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THVFLHNVPL
     CVLESCEFMG SENNSVTVEG HPSADKNWAY KYLLGLIRSS PSLLPTENSD FLMSLDLESR
     DQAWSPRTCD IVIEGSQSPT TPASSSPKPG SKASLQEAEV GSDGERVAQT PDSSDGGLSP
     SGEDEDEDQL TYRLSYQVQG PRPVLGGSFL GPPLPGASIQ LPSCLVLNSL QQELQKDKEA
     MALASSVQGC LIRRCLFRDG KGGVFVCSYG RAKMEGNIFR NLTYAVRCIH NSKIVMLRND
     IYRCRASGIF LRLEGGGLIA GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN
     GKGVIRNNQI FSNKEAGIYI LYHGNPIVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ
     WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG EEGKGLIEGN TIYANKGCGV WMMSSSLPHV
     TSNHVSYNGL YGVAVFSQKD GSSEFPGGHG AQENFSEDGD AILWETELEK EDDPLRRPIT
     IALVESNSIN HNGASGLYVQ SSEALHVITN VIHANGDRGI TVAQSSQLTR VANNSISCNR
     QSGVKVEAQC KVELRGNGIY DNRGHGIITK GDSTVVIEND IIGNRGSGLQ LLPRSDTKVM
     KNRIHSFRAY GIAVRGHTKA LVQENIIFQG KTNKTIFQQI SNNRDCIMQN NKFLVFKKKS
     DTWRLVNPPA RPHLESSLRG PSAAHSGQKV TAMATRITAR VEGGYHSNRS IFCTIL
//