GenomeNet

Database: UniProt
Entry: G5C1K6_HETGA
LinkDB: G5C1K6_HETGA
Original site: G5C1K6_HETGA 
ID   G5C1K6_HETGA            Unreviewed;       380 AA.
AC   G5C1K6;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   05-JUN-2019, entry version 45.
DE   SubName: Full=Proto-oncogene c-Fos {ECO:0000313|EMBL:AIZ08991.1};
DE   SubName: Full=Proto-oncogene protein c-fos {ECO:0000313|EMBL:EHB15417.1};
GN   ORFNames=GW7_01438 {ECO:0000313|EMBL:EHB15417.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15417.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB15417.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
RN   [2] {ECO:0000313|EMBL:AIZ08991.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AIZ08991.1};
RX   PubMed=26763976; DOI=10.1186/s12864-015-2349-8;
RA   Bens M., Sahm A., Groth M., Jahn N., Morhart M., Holtze S.,
RA   Hildebrandt T.B., Platzer M., Szafranski K.;
RT   "FRAMA: from RNA-seq data to annotated mRNA assemblies.";
RL   BMC Genomics 17:54-54(2016).
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DR   EMBL; KM486706; AIZ08991.1; -; mRNA.
DR   EMBL; JH172853; EHB15417.1; -; Genomic_DNA.
DR   RefSeq; NP_001297184.1; NM_001310255.1.
DR   STRING; 10181.XP_004837226.1; -.
DR   GeneID; 101718383; -.
DR   KEGG; hgl:101718383; -.
DR   CTD; 2353; -.
DR   KO; K04379; -.
DR   OrthoDB; 1221590at2759; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR   GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR   GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
DR   GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR   GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR   GO; GO:0042493; P:response to drug; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR   GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   InterPro; IPR000837; AP-1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR029816; c-Fos/v-Fos.
DR   PANTHER; PTHR23351; PTHR23351; 1.
DR   PANTHER; PTHR23351:SF4; PTHR23351:SF4; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   PRINTS; PR00042; LEUZIPPRFOS.
DR   SMART; SM00338; BRLZ; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00843640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   DOMAIN      137    200       BZIP. {ECO:0000259|PROSITE:PS50217}.
FT   REGION      354    380       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G5C1K6}.
FT   COILED      135    196       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    357    380       Polar. {ECO:0000256|MobiDB-lite:G5C1K6}.
SQ   SEQUENCE   380 AA;  40812 MW;  03E5B9D9EAA64C4D CRC64;
     MMFSGFNADY EAASSRCSSA SPAGDNLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF
     IPTVTAISTS PDLQWLVQPT LVSSVAPSQT RAPHPYGVPT PPAGAYSRAG VVKTMNGSRA
     QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ
     TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLSGGLQEA ATPESEEAFT
     LPLLNDPEPK PSVEPVKSIS SMELKAEPFD DFMFPASSRP SGSETARSVP DMDLSGSFYA
     ADWEPLHSGS LGMGPMAAEL EPLCTPVVTC TPSCTTYTSS FVFTYPEADS FPSCAAAHRK
     GSSSNEPSSD SLSSPTLLAL
//
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