ID G5C1Z0_HETGA Unreviewed; 2855 AA.
AC G5C1Z0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE Flags: Fragment;
GN ORFNames=GW7_01328 {ECO:0000313|EMBL:EHB15551.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15551.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB15551.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; JH172942; EHB15551.1; -; Genomic_DNA.
DR STRING; 10181.G5C1Z0; -.
DR MEROPS; C19.067; -.
DR eggNOG; KOG1866; Eukaryota.
DR InParanoid; G5C1Z0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR021905; DUF3517.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF948; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34; 1.
DR Pfam; PF12030; DUF3517; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EHB15551.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 1678..2064
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 286..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2641..2751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2642..2682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2683..2718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2731..2746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB15551.1"
SQ SEQUENCE 2855 AA; 323957 MW; 400ACD9D5BCF3BDD CRC64;
VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM NLTAVMQHII PFRTYVIRYL
CKLSDQELRQ SAARNMADLM WSTVKEPLDT TLCFDKESLD LAFKYFMSPT LTMRLAGLSQ
ITNQLHTFND VCNNESLVSD TETSIAKELA DWLISNNVVE HIFGPNLHIE IIKQCQVILN
FLAAEGRLST QHIDCIWAAA QLKHCSRYIH DLFPSLIKNL DPVPLRHLLN LVSALEPSVH
TEQTLYLASM LIKALWNNAL AAKAQLSKQS SFASLLNTNI PIGNKKEEEE LRRAAPSPWS
PAASPQSSDN SDTHQSGGSD IEMDEQLINR TKHVQQRLSD TEESMQGSSD ETANSGEDGS
SGPGSSSGHS DGSSNEVNSS HASQSAGSPG SEAQSEDIAD IEALKEEDED DDHGHNPPKS
SCGADLRNRK LESQAGICLG DSQGPSERNG TSNGTGKDLV FNTESLPSVD NRIRMLDACS
HSEDPEHDTS GEINAAHIAQ GSQESCITRT GDFLGETIGN ELFNCRQFIG PQHHHHHHHH
HHHHEGHMVD DMLSADDVSC SSSQVSAKSE KNMADFDGEE SGCEEELVQI NSHAELTSHL
QQHLPNLASI YHEHLSQGPA VHKHQFNSSA VTDINLDNVC KKGNTLLWDI VQDDDAVNLS
EGLINEAEKL LCSLVCWFTD RQIRMRFIEG CLENLGNNRS VVISLRLLPK LFGTFQQFGS
SYDTHWITMW AEKELNMMKL FFDNLVYYIQ TVREGRQKHA LYSHSAEVQV RLQFLTCVFS
TLGSPDHFRL SLEQVDILWH CLVEDSECYD DALHWFLNQV RSKDQHAMGM ETYKHLFLEK
MPQLKPETIS MTGLNLFQHL CNLARLATSA YDGGSNSELC GMDQFWGIAL RAQSGDVSRA
AIQYINSYYI NGKTGLEKEQ EFISKCMESL MIASSSLEQE SHSSLMIIER GLLMLKTHLE
AFRRRFAYHL RQWQIEGTGI SSHLKALSDK QSLPLRVVCQ PAGLPDKMTI EMYPSDQVAD
LRAEVTHWYE NLQKEQINQQ AQLQEFGQSS RKGEFPGGLM GPVRMISSGH ELTTDYDEKA
LHELGFKDMQ MVFVSLGAPR RERKGEGVQL PASCLPPPQK DNIPMLLLLQ EPHLTTLFDL
LEMLASFKPP SGKVAVDDSE SLRCEELHLH AENLSRRVWE LLMLLPTCPN MLMAFQNISD
EQSNDGLNWK ELLKIKSAHK LLYALEIIEA LGKPNRRIRR ESTGSYSDLY PDSDDSSEDQ
VENSKNSWSC KFVAAGGLQQ LLEIFNSGIL EPKEQESWAV WQLDCLACLL KLICQFAVDP
SDLDLAYHDV FAWSGIAESH RKRTWPGKSR KAAGDHVKGL HIPRLTEVFL VLVQGTSLIQ
RLMSVAYTYD NLAPRVLKAQ SDHRSRHEVS HYSMWLLVSW AHCCSLVKSS LADSDNLQDW
LKKLTLLIPE TAVRHESCNG LYKLSLSGLD GGDSIHRSFL LLAASTLLKF LPDAQALKPI
RIDDYEEEPM LKPGCKEYFW LLCKLVDNIH IKDASQTTLL DLDALARHLA DCIRSREILD
HQDGNIEDDG LTGLLRLATS VIKHKPPFKF SREGQEFLRD IFNLLFLLPS LKDRQQPKCK
SHSSRAAAYD LLVEMVKGSV ENYRLIHNWV MAQHMQSHAP YKWDYWPHED VRAECRFVGL
TNLGATCYLA STIQQLYMIP EARQAVFTAK YSEDMKHKTT LLELQKMFTY LMESECKAYN
PRPFCKTYTM DKQPLNTGEQ KDMTEFFTDL ITKIEEMSPE LESLDEVTIK DTLEGDNMYT
CSHCGKKVRA EKRYLFNDAE VKPFDSAQLA SECFGGEMTT KTYDSVTDKF MDFSFEKWIW
HDNMQFLQDK NIFEHTYFGF MWQLCSCIPS TLPDPKAVSL MTAKPTMLQW IELLTKQFNN
SQAACEWFLD RMADDDWWPM QILIKCPNQI VRQMFQRLCI HVIQRLRPVH AHLYLQPGME
DGSDDMDASV EDIGGRSCVT RFVRTLLLIM EHGVKPHSKH LTEYFAFLYE FAKMGEEEPQ
VEVLSEEEGE EEEEEEDILS LAEEKYRPAA LEKMIALVAL LVEQSRSERH LTLSQTDMAA
LTGGKGFPFL FQHIRDGINI RQTCNLIFSL CRYNNRLAEH IVSMLFTSIA KLTPEVIEYN
PSQCLDWLAV QTPRNKLAHS WVLQNMENWV ERFLLAHNYP RVRTSAAYLL VSLIPSNSFR
QMFRSTRSLH IPTRDLPLSP DTTVVLHQVY NVLLGLLSRA KLYVDAAVHG TTKLVPYFSF
MTYCLISKTE KLMFSTYFMD LWNLFQPKLS EPAIATNHNK QALLSFWYNV CADCPENIRL
IVQNPVVTKN IAFNYILADH DDQDVVLFNR GMLPAYYGIL RLCCEQSPAF TRQLASHQNI
QWAFKNLTPH ASQYPGAVEE LFNLMQLFIA QRPDMREEEL EDIKQFKKTT ISCYLRCLDG
RSCWTTLISP PELRNACIGV LVAYEGLPLH LALFPKLWTE LCQTQSAMSK NCIKLLCEDP
VFAEYIKCIL MDERTFLNNN IVYTFMTHFL LKVQSQVFSE ANCANLINTL ITNLINQYQN
LQSDFTNRVE ISKASASLNG DLRALALLLS VHTPKQLNPA LIPTLQELLS KCRTCLHQRN
SLQEQEAKER KTKDDEGATP VKRRRVSIDE EHTVDSCISD MKTETREVLT PTSTSDNETR
DSSIIDPGTE QDLPSPENSS VKEYRMEVPS SFSEDMSNIR SQHTEEQSNN GRFEDCKELK
DLHCSKDSTL AEEESEFPST SISAVLSDLA DLRSCDGQGL PSQDPEATLS LSCGHSRGLF
SHMQQHDILD TLCRTIESTI HVVTRISGKG NQAAS
//
