GenomeNet

Database: UniProt
Entry: G5C3L8_HETGA
LinkDB: G5C3L8_HETGA
Original site: G5C3L8_HETGA 
ID   G5C3L8_HETGA            Unreviewed;       480 AA.
AC   G5C3L8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   08-MAY-2019, entry version 36.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit epsilon {ECO:0000313|EMBL:EHB16129.1};
GN   ORFNames=GW7_01060 {ECO:0000313|EMBL:EHB16129.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16129.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB16129.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; JH173156; EHB16129.1; -; Genomic_DNA.
DR   STRING; 10181.XP_004871133.1; -.
DR   InParanoid; G5C3L8; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 2.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EHB16129.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    456    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    168       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      267    362       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   480 AA;  54902 MW;  CBA8EA13D95C0619 CRC64;
     MAATTAVTHA SEAPRAGSKL PEASKILDAM LKNYDNKLHP GIGAKPTVVD VEISVSSLGP
     ISIMDMEYTV DIFLYQSWYD ERLRFNKTFD SFVLSGDMVN NVWTPEAFFV NSKNTMEHSV
     TMPNQMVRIH RNGKVLYAIR MSIVVRCSFH MLKFPMDSHS CPLSFSSSLI PAFIRCNVLE
     LLHWPFIAGQ LANLLTALSY PVTDMIYRLE NFSLEMNKNN TWKLFQFYFT GVSNKTEIVS
     TPAGEFVVTT FFFNVSRRFG YIAIQNYVPP SMTTMLSWVS FWIQRDCAPA RTSLGITSVL
     TMSTLSTFSR KNFPRVSYIT ILDLYITICF IFCFCALLEF AILNYLSYSH KKAHASPILR
     HPPISSARAR ALARARARQQ EEVFVCEIVT SEGSDGKEQI SCSFQELPAP VAPEPPRGRF
     CGSRRCFRKY FCMVPDCEGC TWQRGRLRIH LFRLDNYSRV IFPVTFFFFN VVYWLVCLNL
//
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