ID G5C3Q8_HETGA Unreviewed; 1958 AA.
AC G5C3Q8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Kinesin-like protein KIF1A {ECO:0000313|EMBL:EHB16169.1};
GN ORFNames=GW7_11061 {ECO:0000313|EMBL:EHB16169.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16169.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16169.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; JH173181; EHB16169.1; -; Genomic_DNA.
DR STRING; 10181.G5C3Q8; -.
DR eggNOG; KOG0245; Eukaryota.
DR InParanoid; G5C3Q8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22726; FHA_KIF1A; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR049779; FHA_KIF1A.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 2.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..399
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 561..617
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1843..1941
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1020..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1630..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1768..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 475..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 673..707
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1020..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1065
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1958 AA; 219785 MW; 9736CFB22378D2BA CRC64;
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIINP KQPKETPKSF SFDYSYWSHT
SPEDINYASQ KQVYCDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP
QACGRARQSH WGGCRGWACT GWLSSLGALC EDLFSRINDT TNNNMSYSVE VSYMEIYCER
VRDLLNPKNK GNLRVREHPL LGPYVEDLSK LAVTSYNDIQ DLMDSGNKAR TVAATNMNET
SSRSHAVFNI IFTQKRHDAE TNITTEKDWA EAASLVVQHS RVAGYVSKIS LVDLAGSERA
DSTGAKGTRL KEGANINKSL TTLGKVISAL AEMDSGPNKN KKKKKTDFIP YRDSVLTWLL
RENLGGNSRT AMVAALSPAD INYDETLSTL RYADRAKQIR CNAVINEDPN NKLIRELKDE
VTRLRDLLYA QGLGDITEMT NALVGMSPSS SLSALSSRAA SVSSLHERIL FAPGSEEAIE
RLKETEKIIA ELNETWEEKL RRTEAIRMER EALLAEMGVA MREDGGTLGV FSPKKTPHLV
NLNEDPLMSE CLLYYIKDGI TRVGREDAER RQDIVLSGHF IKEEHCVFRS DTRAGSEAVV
TLEPCEGADT YVNGKKVMEP SILRSGNRII MGKSHVFRFN HPEQARQERE RTPCAETPAE
PVDWAFAQRE LLEKQGIDMK QEMEQRLQEL EDQYRREREE ATYLLEQQRL DYESKLEALQ
KQMESRYYPE VAEEEEEELE DEVQWTEREC ELALWAFRKW KWYQFTSLRD LLWGNAIFLK
EANAISVELK KKVQFQFVLL TDTLYSPLPP DLLPPEAAKD RETRPFPRTI VAVEVQDQKN
GATHYWTLEK LSGMVGHSST FLGSLTGEDA QAQNENVLPG RGSILAPQRG LGVQFQFVLL
TDTLYSPLPP DLLPPEAAKD RETRPFPRPI VAVEVQDQKN GATHYWTLEK LRQRLDLMRE
MYDRAAEVPS SAVEDCENVV TGGDPFYDRF PWFRLVGSSA VSGCSSYPLL NTCMSERMAA
LTPSPTSSSP DSDSEATEPA EEQSVGEEEE EEEEEEEEED LEDDVFLERA LCDGRDPFYD
RSPLFSVVGS LELVIMSTKQ ARETKVSRAF VYLSNLLYPV PLVHRVAIVS EKGEVKGFLR
VAVQAISADE EAPDYGSGVR QSGTAKISFD DQHFEKFQSE SCPVVGMSRS GTSQEELRIV
EGQGQGADVG PSADEVNNNS CSAVPPDGLL LDSPEKATLD HLHLGSTFTF RVTVLQASSI
SAEYADIFCQ FNFIHRHDEA FSTEPLKNTG RGPPLGFYHV QNIAVEVTRS FIEYIKSQPI
VFEVFGHYQQ HPFPPLCKDV LSPLRPSRRH FPRVMPLSKP VPATKLSTLT RPCPGPCHCK
YDLLVYFEIC ELEANGECSE RWTVWLSTFV LLSARRIRNT PETDESLIDP NILSLNILSS
GYLHPAQDDR QFLDSDIPRQ QKRRSPFPHT LLLRLQLTGC LHPLRSTVGC WGLLASTGME
NCMQPAVVTK DFCMVFYSRD AKLPASRSIR NLFGSGSLRA AEGNRVTGVY ELSLCHVADA
GSPGMQRRRR RVLDTSVAYV RGEENLAGWR PRSDSLILDH QWELEKLSLL QEVEKTRHYL
LLREKLETTQ RPGPEALSPA SSEDSESRSS SGASSPLSAE GRPSPLEAPS ERQRELTVKC
LRLLMHTFNR EYTHSHVCIS ASESKLSEMS VTLLRDPSMS PLGAATLTPS STCPSLVEGR
YGSPDVRWLS EMSVTLLRDP SMSPLGAATL TPSSTCPSLV EGRYGSPDVR TPQPCSRPSS
PEPELVPETH SKKPPSPVQA AESEKEPQRL LVPDIQEIRV SPIVSKKGYL HFLEPHTAGW
AKRFVVVRRP YAYMYNSDKD TVERFVLNLS TAQVEYSEDQ QAMLKTPNTF AVCTEHRGIL
LQASSDKDMH DWLYAFNPLL AGTIRSKLSR RRSAQMRV
//
