ID G5C3S7_HETGA Unreviewed; 457 AA.
AC G5C3S7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN ORFNames=GW7_11080 {ECO:0000313|EMBL:EHB16188.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16188.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16188.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC (2->8)- glycosidic linkages of terminal sialic acid residues in
CC oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC synthetic substrates.; EC=3.2.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000427};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
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DR EMBL; JH173181; EHB16188.1; -; Genomic_DNA.
DR RefSeq; XP_004868566.1; XM_004868509.1.
DR RefSeq; XP_004868567.1; XM_004868510.1.
DR AlphaFoldDB; G5C3S7; -.
DR STRING; 10181.G5C3S7; -.
DR GeneID; 101724302; -.
DR KEGG; hgl:101724302; -.
DR CTD; 129807; -.
DR eggNOG; ENOG502QSFT; Eukaryota.
DR InParanoid; G5C3S7; -.
DR OMA; GRTWHCG; -.
DR OrthoDB; 5482010at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000003691; Expressed in hypothalamus and 1 other cell type or tissue.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0019866; C:organelle inner membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006689; P:ganglioside catabolic process; IEA:Ensembl.
DR GO; GO:0006516; P:glycoprotein catabolic process; IEA:Ensembl.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0009313; P:oligosaccharide catabolic process; IEA:Ensembl.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 2.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF22; SIALIDASE-4; 1.
DR Pfam; PF13088; BNR_2; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 57..261
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
FT REGION 306..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 49142 MW; 564AA5E057ADEB51 CRC64;
MGSPRVPART VLFRRERTGL TYRVPALLCI PPRPTLLAFA EQRQSPDDAH AHRLVLRRGA
LAAGGVRWGA LRVLATAALE EHRSMNPCPV TDAGSGTVFL FFIAVLGHTP EAVQIATGRN
AARLCCVTSH DAGLTWGGAR DLTEETLGAQ AQDWATFAVG PGHGIQLPSG RLLVPAYTYR
VDRRECFGKI CRTSPHSFAI YSDDQGRTWH CGGLVPNLRS GECQLAAVGG SFLYCNARSP
LGSRVQSLSA DEGTSFLPAE LVPTLAETAR GCQGSIVGFP APTPSREEEP NPPHLCPGVQ
DPLSGPFCHP QPWENSQEQP GPEPGLGGDG EAYTPMLPLP SVAPAQSPTW LLYSHPVGHR
ARLRMGIYLS RSPLDPHSWT EPWVIYEGPS GYSDLATLGS GPGAALAFAC LFESGVRASY
EDISFCMFSL REVLENVSGG PEMLHRSGKP WEHCRPS
//
