ID   G5C471_HETGA            Unreviewed;       725 AA.
AC   G5C471;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Acid trehalase-like protein 1 {ECO:0000313|EMBL:EHB16332.1};
GN   ORFNames=GW7_07592 {ECO:0000313|EMBL:EHB16332.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16332.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB16332.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC       {ECO:0000256|ARBA:ARBA00006768}.
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DR   EMBL; JH173280; EHB16332.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5C471; -.
DR   STRING; 10181.G5C471; -.
DR   InParanoid; G5C471; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR   PANTHER; PTHR11051:SF8; PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 2.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   DOMAIN          288..424
FT                   /note="Glycoside hydrolase family 65 central catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF03632"
FT   DOMAIN          452..526
FT                   /note="Glycoside hydrolase family 65 central catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF03632"
SQ   SEQUENCE   725 AA;  79669 MW;  79FA8A6384FDA836 CRC64;
     MEDAQPDPTV FASHSLPRDP RLLATVTNVY LGTRVYHDTL HVSGVYNGAR GSTHRAVLPS
     PLNVRLEAPA GKGAQLTQTF ALDTNTGSFL HTLEGPSFRA SQRIYAHRVL PHVLAFRVSI
     ARVAVGSRPI KVLLRSAFSP ESPDLDLHLG PEFQGFRYLW GLTLTPEQPG GPRQEVHMLW
     TPVPPALTLG EGEETRTWDF LTVVGGSRVE AQGCLNEALQ LQATGSLYAI HMQAWAQFWT
     GCSLDVAGPL ALCQAVRSSF YYLFSALPQP GTSGHVSHGL SPGGLSNGSQ RECYWGHVFW
     DQDLWMFPNI LMFHPEAARA LLEYRVRTLG GALENARALN YQGAKFAWES AASGLEVCPE
     DIYGAQEIHI NGAVVLAFQL YYHATQDLQF FREAGGWDVV SAVAEFWCSR VEWNPKEKKF
     DLRGAGLGRR AGRQECGCSW AAHADCCTMC CGGLMCPGVM PPDEYHAGVD NSVYTNVLVQ
     NSLHFAAALA RDLGQPFPDK WLVVADGIEV PFDPEQNFHP EFDGYKPGEE VKQADVVLLG
     YPVPFPLSPD VRRRNLEIYE AVTSPRGPAM TWSMFAVGWM ELKDPSRAQS LLDRNITNVT
     EPFKVWTENA DGSGAVNFLT GMGGFLQAVL FGCTGFRVTC RGVTFDPLCL TDISRVCVSG
     IFYRGNRLNF TFCKDSVMVE VTAQAWPGAP QLEAELWPSG AQLPLLLGHK VSFPCSAGRI
     QRSLP
//