ID G5C4H5_HETGA Unreviewed; 375 AA.
AC G5C4H5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Pulmonary surfactant-associated protein D {ECO:0000313|EMBL:EHB16436.1};
GN Name=SFTPD {ECO:0000313|EMBL:JAN96027.1};
GN ORFNames=GW7_13742 {ECO:0000313|EMBL:EHB16436.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16436.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16436.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN96027.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thyroid {ECO:0000313|EMBL:JAN96027.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Oligomeric complex of 4 set of homotrimers.
CC {ECO:0000256|ARBA:ARBA00011267}.
CC -!- SIMILARITY: Belongs to the SFTPD family.
CC {ECO:0000256|ARBA:ARBA00007899}.
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DR EMBL; JH173383; EHB16436.1; -; Genomic_DNA.
DR EMBL; GEBF01007605; JAN96027.1; -; Transcribed_RNA.
DR AlphaFoldDB; G5C4H5; -.
DR STRING; 10181.G5C4H5; -.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; G5C4H5; -.
DR OMA; EMFTNGK; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd03591; CLECT_collectin_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 1.20.5.360; SFTPD helical domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR033990; Collectin_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR015097; Surfac_D-trimer.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1101; MACROPHAGE RECEPTOR MARCO; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF09006; Surfac_D-trimer; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57944; Triple coiled coil domain of C-type lectins; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..375
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007661187"
FT DOMAIN 260..374
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 45..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 37629 MW; E6F14A28AAEFEAA5 CRC64;
MMLPLLSMLF LLTQPPSYLG AGMTSYQQTT LANACTLVVC SPTENGFPGH DGQDRREGPR
GEKGDPGLPG VVGPAGIPGQ AGPVGPKGDN GFPGEPGPKG DSGPSGPPGP PGVPGPLGKD
GPSGKQGNIG PQGKPGPKGE AGPKGEVGAP GVQGSAGTRG PTGPKGEKGT PGELGAPGSA
GAVGPAGAAG PQGAPGSRGP PGLKGDRGAP GDKGAKGESG LPDIAALKQQ VEALRRQLQT
LQASFSHCKK AELFPNGQSV GDKIFKTVGS EANFEGAQKM CTQAGGQLPS PRSAAENAAL
QKLIEAQNKA AFLSLTDTKK EGTFVYPSGE LLVYSNWAPG EPNNHGGSEN CVEMFTNGKW
NDKDCGQHRL VICEF
//
