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Database: UniProt
Entry: G5C4N4_HETGA
LinkDB: G5C4N4_HETGA
Original site: G5C4N4_HETGA 
ID   G5C4N4_HETGA            Unreviewed;       577 AA.
AC   G5C4N4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Insulin-like growth factor 2 mRNA-binding protein 1 {ECO:0000313|EMBL:EHB16461.1};
GN   ORFNames=GW7_21752 {ECO:0000313|EMBL:EHB16461.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16461.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB16461.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC       {ECO:0000256|ARBA:ARBA00004210}.
CC   -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC       {ECO:0000256|ARBA:ARBA00009094}.
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DR   EMBL; JH173384; EHB16461.1; -; Genomic_DNA.
DR   RefSeq; XP_004859692.1; XM_004859635.2.
DR   AlphaFoldDB; G5C4N4; -.
DR   SMR; G5C4N4; -.
DR   STRING; 10181.G5C4N4; -.
DR   GeneID; 101718854; -.
DR   CTD; 10642; -.
DR   eggNOG; KOG2193; Eukaryota.
DR   InParanoid; G5C4N4; -.
DR   OMA; RWEVSET; -.
DR   OrthoDB; 3035007at2759; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   Bgee; ENSHGLG00000010492; Expressed in testis and 4 other cell types or tissues.
DR   GO; GO:0070937; C:CRD-mediated mRNA stability complex; IEA:Ensembl.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR   GO; GO:0048027; F:mRNA 5'-UTR binding; IEA:Ensembl.
DR   GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:Ensembl.
DR   GO; GO:0045182; F:translation regulator activity; IEA:Ensembl.
DR   GO; GO:0070934; P:CRD-mediated mRNA stabilization; IEA:Ensembl.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:1900152; P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Ensembl.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR   GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR   GO; GO:0022013; P:pallium cell proliferation in forebrain; IEA:Ensembl.
DR   GO; GO:2000767; P:positive regulation of cytoplasmic translation; IEA:Ensembl.
DR   GO; GO:0010610; P:regulation of mRNA stability involved in response to stress; IEA:Ensembl.
DR   CDD; cd22490; KH-I_IGF2BP1_rpt1; 1.
DR   CDD; cd22493; KH-I_IGF2BP1_rpt2; 1.
DR   CDD; cd22496; KH-I_IGF2BP1_rpt3; 1.
DR   CDD; cd22499; KH-I_IGF2BP1_rpt4; 1.
DR   CDD; cd12628; RRM2_IGF2BP1; 1.
DR   Gene3D; 3.30.310.210; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR   InterPro; IPR034842; IGF2BP1_RRM2.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR10288:SF92; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR   Pfam; PF00013; KH_1; 4.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00322; KH; 4.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 4.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}; Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          2..75
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          81..156
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          155..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   577 AA;  63463 MW;  8CD47A0C91626C01 CRC64;
     MNKLYIGNLN ESVTPADLEK VFAEHKISYS GPFLVKSGYA FVDCPDEHWA MKAIETFSGK
     VELQGRRLEI EHSVPKKQRS RKIQIRNIPP QLRWEVLDSL LAQYGTVENC EQVNTESETA
     VVNVTYSNRE QTRQAIMKLN GHQLENHALK VSYIPDEQIS QGPENGRRGG FGSRGQPRQG
     SPVAAGAPAK QQQVDIPLRL LVPTQYVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA
     EKAISVHSTP EGCSSACRMI LEIMHKEAKD TKTADEVPLK ILAHNNFVGR LIGKEGRNLK
     KVEQDTETKI TISSLQDLTL YNPERTITVK GAIENCCRAE QEITKKVREA YENDVAAMSL
     QSHLIPGLNL AAVGLFPASS SAVPPPPSSV SGAAPYSSFM QAPEQEMVQV FIPAQAVGAI
     IGKKGQHIKQ LSRFASASIK IAPPETPDSK VRMVIITGPP EAQFKAQGRI YGKLKEENFF
     GPKEEVKLET HIRVPASAAG RVIGKGGKTV NELQNLTAAE VVVPRDQTPD ENDQVVVKII
     GHFYASQMAQ RKIRDILAQV KQQHQKGQSN QAQARRK
//
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