ID G5C5S1_HETGA Unreviewed; 716 AA.
AC G5C5S1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN ORFNames=GW7_19229 {ECO:0000313|EMBL:EHB16882.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16882.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16882.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; JH173457; EHB16882.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C5S1; -.
DR STRING; 10181.G5C5S1; -.
DR eggNOG; KOG0239; Eukaryota.
DR InParanoid; G5C5S1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47972:SF67; KINESIN MOTOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47972; KINESIN-LIKE PROTEIN KLP-3; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..716
FT /note="Kinesin-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475115"
FT DOMAIN 310..657
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..134
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 177..218
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 667..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 385..392
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 716 AA; 77190 MW; 7B45FADE423C7010 CRC64;
MYAFYSLLIY IFYSLFRRDG GAAATADPGD PAQRARCKTR GRRHPDQLTS ELWAELTGLA
GFSLQEESPS PGPGEVLSVE AQGQQTSQLE EEQRAWHRLE QLILGQLEEL KQQLEQQEEE
LGRLRLEVGA TDSEKRVRHL TLENEALKQS LSLTRDLLLH WGSSPSTSTP QEEVEALLEL
QGRLQEAQDT TEALRVQLGV QEVQLQGLRG ALQQLQQETE QNCRRELEQV HGQLAGLRAR
MASLRQGCGD LRGLVSTFSQ SCQGSLSEAR GQVSWALGAL SAGGAGTQPS DEHQASPTGC
QGRLLELKGN IRVLCRLRPG TPSSLVSVEP GPGGTVTTCY RGRQRRFCLD WVFPQDASQE
QVFRELEPAV LSCLRGYSVC IFTYGQTGTG KTYSMEGPPE DPGIAPRALQ SLFREMGVGG
QHRVTLSMVE IYNEAVRDLL APGPPQRLAV RQGPAGQGGI QVAGLTHWDV PNLETLHQML
SVGRSNRATA ATAMNTRSSR SHALVTLTLR AAYPPRGPSP SGTLHLVDLA GSERAWKAGV
ASAARGDPKS VQRLREAQTI NRSLLALGGV MAALRSRRPH VPFRDSQLTR LLQPALGPGA
TAVLLLQVGA NGSAGVGEQG ACSGSAHQCY FLQISTRLED LGETVCSLKF AERVGQVELG
PARRQKTPRS GTPSSLSTDT PLTETPCTPT PSPGSQSPGP HGDSGLAFAP PEDLPP
//
