ID G5C5W8_HETGA Unreviewed; 474 AA.
AC G5C5W8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Paralemmin-1 {ECO:0000256|ARBA:ARBA00040790};
DE AltName: Full=Paralemmin {ECO:0000256|ARBA:ARBA00041963};
GN ORFNames=GW7_08105 {ECO:0000313|EMBL:EHB16929.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16929.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16929.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBUNIT: Interacts with dopamine receptor DRD3.
CC {ECO:0000256|ARBA:ARBA00038823}.
CC -!- SUBCELLULAR LOCATION: Apicolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037796}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00037796}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037871}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00037871}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004342}. Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium membrane
CC {ECO:0000256|ARBA:ARBA00004527}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004527}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037829}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00037829}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the paralemmin family.
CC {ECO:0000256|ARBA:ARBA00005756}.
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DR EMBL; JH173462; EHB16929.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C5W8; -.
DR STRING; 10181.G5C5W8; -.
DR eggNOG; ENOG502QQ2W; Eukaryota.
DR InParanoid; G5C5W8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016327; C:apicolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:InterPro.
DR InterPro; IPR004965; Paralemmin.
DR PANTHER; PTHR10498:SF6; PARALEMMIN-1; 1.
DR PANTHER; PTHR10498; PARALEMMIN-RELATED; 1.
DR Pfam; PF03285; Paralemmin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REGION 130..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 51105 MW; 10D665006F204444 CRC64;
MEPDYCSTWT GGFHLLWSTG CGLAVAPTQP EHAALCALDV HSARRPALLS LWDRGVPSPL
PEPRSSGQVL PGVAAGGRGF TGVWWVLEVV ECCEDPCEER RKRQAEIENK RRQLEDDRRQ
LQHLKSKALR ERWLLEGTPS SASEGDEDMR RQMQEDEQRA RLLEGSISRL EKEIDLLENG
EVAPATSKNA AVPSPARAPA PSPAREEPKA EVVLNSQQTA AGTPKAEQRV SNTPVRTADG
STMMKAAMYS VEITVEKDKV TGETRVLSST TLLPRDPHPQ GIKVYEDETK VVHAVDGTVE
NGIHPLSSSE VDELIHKADE VTLSEAEAGA GAGAAAETRG SAVAVAVEET VRNTPLRREI
TGVQAQPGEA TSGLASAQPS QEPPVTMIFM GYQNVEDESE TKKVLGLQDT ITAELVVIED
AAEPTEAAPP NGSAPEAPAA PSSREEDRAR PEATTSDPQD LDLKKQRCKC CSVM
//
