ID G5C7S2_HETGA Unreviewed; 1116 AA.
AC G5C7S2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Structural maintenance of chromosomes protein 1B {ECO:0000313|EMBL:EHB17583.1};
GN ORFNames=GW7_10206 {ECO:0000313|EMBL:EHB17583.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17583.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17583.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC1 subfamily.
CC {ECO:0000256|ARBA:ARBA00005597}.
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DR EMBL; JH173699; EHB17583.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C7S2; -.
DR STRING; 10181.G5C7S2; -.
DR eggNOG; KOG0018; Eukaryota.
DR InParanoid; G5C7S2; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0008278; C:cohesin complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProt.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03275; ABC_SMC1_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR028468; Smc1_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF147; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1B; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 3.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 466..582
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 158..219
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 263..346
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1116 AA; 128890 MW; 54BBB81859A5582E CRC64;
MGYLKVLLVE NFKSWRGRQV IGPFERFTCI IGPNGSGKSN IMDALSFVMG EKITNLRVKS
IQELIHGAHV GKPVSSSASV RIVYVEESGE EKTFARIIRG GCSEFYFGDN PVTRSAYIAE
LEKIGIIGKA RNCLVFQGTV ELISMKKPKE RTRFFEEIST SGELMEEYEE KKRKLQKAEE
NAQFNFNKKK NAAAERKHAK LEKEEADRYQ SLLEELKTNK IQLQLFQLYH NEKKIHFLNV
ELEHVNRDLS VMKESHFHHE NIVKAKKKEH GMLTRQLQQT EKELKSLEAL LNQKRPQYIK
AKENTSHHLK KLDISKKSIK DCEKQCSKQE DDIRALQAEL VDLDSAWKSF EKQIEEEILH
KERGIELEPS QGNLKQIKEQ IEDHKKRIEK LEEYIKTCMD FLNEKRQHEE TLVDEIGKAK
SRMSDVNEEL NRIMSDLQNA GIDKHEGKRE QKRAEVLEHL KRLYPDSVFG RLLDLCHPIH
KKYQLAVTKL FGRYMVAIVV TSEKVAKDCI RFLKEERAEP ETFLALDYLD IKPINERLRE
IKGCKMMIDV IKTQFPQLKK VIQFVCGNGL VCETVEEARH IAFGGPERRK TVALDGTLFL
KSGVISGGSS DLKHKARCWD EKELKNLRDR RNQLVQELKD LMKILRKETD LKQIQTLAQG
THTRLRYSQS EVEIIKKKHL VAAHRVEDEI FHDFCEEIGL ENIREFENKH VKQQQEIDQK
RLEFEKQKTR LNIQLEYSRS LLKKKLSKIN TLKETIQKGG EDIDSLKKIE YNCLQVVDEL
MAKQKQLKDI FVTQNSSAQK VQSQLEEERK KFLAVDREVG KLQKEVVIIQ TSLEQKRLER
HNMLLDCKVQ NIEITLLLGS LDDIIEVELG TETESTQATT DIYEKEAAME VDYSPLQEDL
KALLSDKEVE ARLVLLVQQV ASQEENLLKT AAPNLRALQK LKTVRDKFQE STDAFEASRK
EARMCRQEFE QVKKRRYDLF NQCFEHVSVS IDHIYKKLCR NHSAQAFLSP ENPEEPYLEG
ISYNCVAPGK RFMPMDNLSG GERCVAALAL LFAVHSFRPA PFFVLDEIDA ALDNTNIGKV
SCFLLLVFIL MSAIPGSWCG QKTAYLNTQG GASGCC
//
