ID G5C7Z8_HETGA Unreviewed; 1498 AA.
AC G5C7Z8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Plexin-A4 {ECO:0000313|EMBL:EHB17659.1};
DE Flags: Fragment;
GN ORFNames=GW7_20419 {ECO:0000313|EMBL:EHB17659.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17659.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17659.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; JH173776; EHB17659.1; -; Genomic_DNA.
DR STRING; 10181.G5C7Z8; -.
DR eggNOG; KOG3610; Eukaryota.
DR InParanoid; G5C7Z8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF34; PLEXIN-A4; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 842..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..111
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 868..895
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1498
FT /evidence="ECO:0000313|EMBL:EHB17659.1"
SQ SEQUENCE 1498 AA; 168350 MW; 1678BE87EC74F38A CRC64;
LLTIDDNFCG LDMNAPLGVS EMVRGIPVFT EDRDRMTSII AYVYKNHSLA FVGTKSGKLK
KIRVDGPRGN ALQYETVQVV DPGPVLRDMA FSKDHEQLYI MSERQLTRVP VESCSQYRSC
SECLGSGDPH CGWCVLHNTC TRKERCERSR EPRRFASEMK QCVRLTVHPN NISVSQYNVL
LVLETYNVPE LSAGVNCTFE DLSEMDGLVV GNQIHCYSPA AKEVPRIITE NGDHHVVQLQ
LKSKETGMTF ASTSFVFYNC SVHNSCLSCV ESPYRCHWCK YRHVCTHDPK TCSFQEGRVK
LPEDCPQLLR VDKILVPVEV IKPITLKAKN LPQPQSGQRG YECILNIQGS EQRVPALRFN
SSSVQCQNTS YSYEGMEINN LPVELTVVWN GHFNIDNPAQ NKVHLYKCGA MRESCGLCLK
ADPDFECGWC QNPGQCTLRQ HCPAHESRWL ELSGANSKCT NPRITEIIPV TGPREGGTKV
TIRGENLGLE FRDIASHVKV AGVECSPLVD GYIPAEQIVC EMGEAKPSQH AGFVEICVAL
CRPEFMARSS QLYYFMTLTL LDLKPSRGPM SGGTQVTITG TNLNAGSNVV VMFGKQPCLF
HRRSPSFIVC NTTSSDEVLE MKVTVQVDRA RIRQDLVFQY VEDPTIVRIE PEWSIVSGNT
PIAVWGTHLD LIQNPQIRAK HGGKEHINIC EVLNATEMTC QAPALALDPD YQSDLTERPE
EFGFILDNVQ SLLILNKTNF TYYPNPVFEA FGPSGILELK PGTPIILKGK NLIPPVAGAN
VKLNYTVLVG EKPCTVTVSD VQLLCESPTL IGRHKVMARV GGMEYSPGMV YIAPDSPLSL
PAIISIAVAG GLLIIFIVAV LIAYKRKSRE SDLTLKRLQM QMDNLESRVA LECKEAFAEL
QTDIHELTSD LDGAGIPFLD YRTYTMRVLF PGIEDHPVLR DLEVPGYRQE RVEKGLKLFA
QLINNKVFLL SFIRTLESQR SFSMRDRGNV ASLIMTVLQS KLEYATDVLK QLLADLIDKN
LESKNHPKLL LRRTESVAEK MLTNWFTFLL YKFLKECAGE PLFSLFCAIK QQMEKGPIDA
ITGEARYSLS EDKLIRQQIE YKTLVLSCVS PDNANSPEVP VKILNCDTIT QVKEKILDAI
FKNVPCSHRP KAADMDLEWR QGSGARMILQ DEDITTKIEN DWKRLNTLAH YQVPDGSVVA
LVSKQVTAYN AVNNSTVSRT SASKYENMIR YTGSPDSLRS RTPMITPDLE SGVKMWHLVK
NHEHGDQKEG DRGSKMVSEI YLTRLLATKG TLQKFVDDLF ETIFSTAHRG SALPLAIKYM
FDFLDEQADK HGIHDPHVRH TWKSNCLPLR FWVNMIKNPQ FVFDIHKNSI TDACLSVVAQ
TFMDSCSTSE HRLGKDSPSN KLLYAKDIPS YKSWVERYYS DIGKMPAISD QDMNAYLAEQ
SRMHMNEFNT MSALSEIFSY VGKYSEEILG PLDHDDQCGK QKLAYKLEQV ITLMSLDS
//
