ID G5C870_HETGA Unreviewed; 140 AA.
AC G5C870;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Vesicle-associated membrane protein 4 {ECO:0000313|EMBL:EHB17731.1};
DE Flags: Fragment;
GN ORFNames=GW7_07722 {ECO:0000313|EMBL:EHB17731.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17731.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17731.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
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DR EMBL; JH173800; EHB17731.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C870; -.
DR STRING; 10181.G5C870; -.
DR Ensembl; ENSHGLT00000018494; ENSHGLP00000018310; ENSHGLG00000013119.
DR Ensembl; ENSHGLT00100003339; ENSHGLP00100003280; ENSHGLG00100002501.
DR eggNOG; KOG0860; Eukaryota.
DR InParanoid; G5C870; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090161; P:Golgi ribbon formation; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd15869; R-SNARE_VAMP4; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR001388; Synaptobrevin-like.
DR InterPro; IPR042855; V_SNARE_CC.
DR InterPro; IPR042887; VAMP4.
DR PANTHER; PTHR46897; VESICLE-ASSOCIATED MEMBRANE PROTEIN 4; 1.
DR PANTHER; PTHR46897:SF1; VESICLE-ASSOCIATED MEMBRANE PROTEIN 4; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..111
FT /note="V-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50892"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB17731.1"
SQ SEQUENCE 140 AA; 16271 MW; 1EB2C75CA219944D CRC64;
IPPKFKRHLN DDDVTGSVGC ERRSLLEDDS DEEDFFLRRP SGPRFGPRND KINHVQNQVD
EVIDVMKENI TKVIERGERL DELQDKSESL SDNATAFSNR FKQLRRQMWW CGCKIKAIMA
LVAVFLLLVI IILIVVKYHT
//
