ID   G5C8C2_HETGA            Unreviewed;       201 AA.
AC   G5C8C2;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=ADP-ribosylation factor-related protein 1 {ECO:0000256|ARBA:ARBA00039478};
GN   Name=ARFRP1 {ECO:0000313|EMBL:JAO00967.1};
GN   ORFNames=GW7_09722 {ECO:0000313|EMBL:EHB17783.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17783.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB17783.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
RN   [2] {ECO:0000313|EMBL:JAO00967.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:JAO00967.1};
RA   Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA   Platzer M., Szafranski K.;
RT   "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting.
CC       Controls the targeting of ARL1 and its effector to the trans-Golgi.
CC       Required for the lipidation of chylomicrons in the intestine and
CC       required for VLDL lipidation in the liver.
CC       {ECO:0000256|ARBA:ARBA00037377}.
CC   -!- SUBUNIT: Interacts with SYS1. {ECO:0000256|ARBA:ARBA00038765}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000256|ARBA:ARBA00010290}.
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DR   EMBL; JH173809; EHB17783.1; -; Genomic_DNA.
DR   EMBL; GEBF01002666; JAO00967.1; -; Transcribed_RNA.
DR   RefSeq; XP_004841148.1; XM_004841091.2.
DR   RefSeq; XP_004841149.1; XM_004841092.2.
DR   RefSeq; XP_004841150.1; XM_004841093.2.
DR   RefSeq; XP_004841151.1; XM_004841094.2.
DR   AlphaFoldDB; G5C8C2; -.
DR   STRING; 10181.G5C8C2; -.
DR   Ensembl; ENSHGLT00100055207; ENSHGLP00100051498; ENSHGLG00100004198.
DR   GeneID; 101726466; -.
DR   KEGG; hgl:101726466; -.
DR   CTD; 10139; -.
DR   eggNOG; KOG0076; Eukaryota.
DR   InParanoid; G5C8C2; -.
DR   OMA; HGFYKYM; -.
DR   OrthoDB; 5349301at2759; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   Bgee; ENSHGLG00000012078; Expressed in zone of skin and 10 other cell types or tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd04160; Arfrp1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR45909; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR   PANTHER; PTHR45909:SF1; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
SQ   SEQUENCE   201 AA;  22759 MW;  FF80F3D00D7F88E0 CRC64;
     MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMNL SKITTTVGLN
     IGTVDIGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLSE SKQAFEKVVS
     SEALDGVPIL VLANKQDVET CLSIPDIKTA FSDCSYKIGR RDCLTQACSA LTGKGVREGI
     EWMVKCVVRN IHRPPRQRDI T
//