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Database: UniProt
Entry: G5C8R0_HETGA
LinkDB: G5C8R0_HETGA
Original site: G5C8R0_HETGA 
ID   G5C8R0_HETGA            Unreviewed;       355 AA.
AC   G5C8R0;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   08-MAY-2019, entry version 30.
DE   RecName: Full=Glucose-6-phosphatase {ECO:0000256|PIRNR:PIRNR000905};
DE            EC=3.1.3.9 {ECO:0000256|PIRNR:PIRNR000905};
GN   ORFNames=GW7_06213 {ECO:0000313|EMBL:EHB17921.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17921.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB17921.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000256|PIRNR:PIRNR000905}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|PIRNR:PIRNR000905}.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphatase family.
CC       {ECO:0000256|PIRNR:PIRNR000905}.
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DR   EMBL; JH173922; EHB17921.1; -; Genomic_DNA.
DR   RefSeq; XP_004857674.1; XM_004857617.1.
DR   STRING; 10181.XP_004857674.1; -.
DR   GeneID; 101715644; -.
DR   KEGG; hgl:101715644; -.
DR   CTD; 57818; -.
DR   InParanoid; G5C8R0; -.
DR   KO; K01084; -.
DR   OrthoDB; 743717at2759; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004346; F:glucose-6-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
DR   InterPro; IPR016275; Glucose-6-phosphatase.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   Pfam; PF01569; PAP2; 1.
DR   PIRSF; PIRSF000905; Glucose-6-phosphatase; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR000905};
KW   Gluconeogenesis {ECO:0000256|PIRNR:PIRNR000905};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR000905};
KW   Membrane {ECO:0000256|PIRNR:PIRNR000905, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     57     76       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    194       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    292    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    330    347       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       53    194       acidPPc. {ECO:0000259|SMART:SM00014}.
FT   ACT_SITE    115    115       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000905-1}.
FT   ACT_SITE    174    174       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000905-1}.
FT   BINDING      79     79       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000905-2}.
FT   BINDING     168    168       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000905-2}.
SQ   SEQUENCE   355 AA;  41021 MW;  3791F23882747785 CRC64;
     MDFLHRNGVL IIQHLQKDYR AYYDFLNFMS NVGDPRNIFS IYFPLWFQLN QTVGTKMIWV
     AVIGDWFNLI FKWVLFGHRP YWWVQETQIY QNHSSSCLEQ FPTTCETGPG SPSGHAMGSS
     CVWYVMVTAA LSRSVSPMDK FSVTRHRLTW SFLWSLFWLI QISVCISRVF IATHFPHQVI
     LGVIGGMLVA EAFEHTPSLH MASLSTYLKT NLFLFLFALG FYLLLRLLNI DLLWSVPIAK
     KWCANPDWIH IDTTPFAGLV RNLGVFFGLG FAINSEMFLL SCRGENGYKL SFRVLCSMTS
     LATLQLYHFI KIPTHTEHLF YMLSFCKSAS IPLTVVALIP YCIHMLMKPN EKKFK
//
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