ID G5C954_HETGA Unreviewed; 372 AA.
AC G5C954;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Solute carrier family 10 member 6 {ECO:0000313|EMBL:EHB18065.1};
DE Flags: Fragment;
GN ORFNames=GW7_17534 {ECO:0000313|EMBL:EHB18065.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18065.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB18065.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
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DR EMBL; JH173954; EHB18065.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C954; -.
DR STRING; 10181.G5C954; -.
DR eggNOG; KOG2718; Eukaryota.
DR InParanoid; G5C954; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00841; bass; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361:SF55; SOLUTE CARRIER FAMILY 10 MEMBER 6; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 348..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB18065.1"
SQ SEQUENCE 372 AA; 40498 MW; 355309A28D738DA1 CRC64;
MTANYSGSSA CPANSSEEAL PGTPEVHGSL ELVFTVVSAV MMAMVMFSLG CSVDMQKLWW
HLRRPWGVAV GLVCQFGLMP LTAYLLAISF SLKPVQAVAV LIMGCCPGGT ISNIFTFWVD
GDMDLSITMT TCSTVAALGM MPLCLYLYTW SWDLAQNLTI PYQNIGLTLL CLTIPVAFGV
FVNYKWPKQS KIILKVGAIV GGLLLLVVTV AGVVLSKEFW NSDTTLLTIS FLFPLIGHIS
GFLLALLTHQ SWQRCRTISL ETGAQNIQMC LTMLQLSFTA EHLVQMFNFP LAYGFFQMLD
GLLIVTAYQV YKNMKNKHRQ KSPDCAEVPP EQKPKETSAF LEWDEAAAVN PGPSGPGGHL
GALGPSSLLT SC
//
