ID G5C9G9_HETGA Unreviewed; 461 AA.
AC G5C9G9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Interleukin-7 receptor subunit alpha {ECO:0000256|ARBA:ARBA00018930};
GN ORFNames=GW7_08011 {ECO:0000313|EMBL:EHB18180.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18180.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB18180.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Receptor for interleukin-7. Also acts as a receptor for
CC thymic stromal lymphopoietin (TSLP). {ECO:0000256|ARBA:ARBA00025125}.
CC -!- SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP
CC receptor is a heterodimer of CRLF2 and IL7R.
CC {ECO:0000256|ARBA:ARBA00025831}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
CC subfamily. {ECO:0000256|ARBA:ARBA00008280}.
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DR EMBL; JH174051; EHB18180.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C9G9; -.
DR STRING; 10181.G5C9G9; -.
DR Ensembl; ENSHGLT00100057716; ENSHGLP00100051663; ENSHGLG00100052109.
DR eggNOG; ENOG502S4WE; Eukaryota.
DR InParanoid; G5C9G9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.1870; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR040997; FN3_7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF27; INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF18447; FN3_7; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EHB18180.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..461
FT /note="Interleukin-7 receptor subunit alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475344"
FT TRANSMEM 243..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..234
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 461 AA; 51980 MW; 31B72CD5C83B582C CRC64;
MTILGTAFAI VFYLLYTVSG ESGYAQNGDL EDAESDTDYS FSCYAQLEVD GSQHSLTCAF
DDPDINSTNL ELEICKGFVG VECMNFSKLQ EEKYFIKTKK FLLVGESKIC VKLGEETLAC
KTVEIAHLVK PEAPFDMKVI YRDRANDFEV TFNTSHLQKK YVKQLMHDVA YCQEKNGNNW
THMNIFNTRL TLPLRKLQSD AMYEIKVRSI PDSDYYKGFW SEWSPSSHFK TPEANNAEEM
NPVLSTISIT SFFSVVLLVI LSCALWKKRI KPIVWPSLPD HKKTLEQLCK KPEKNLNVSF
NPEHFLDCQI HKVDDIQSRD EVESFLQDTL SPQFEESEKQ GFAGSGQGHN WPSQIPVITS
EAFKGELPFG CPTGNVSACN ASMHPSFWSP DCRKGIRSGS HMYQGLLLSP GTTDSTVLPP
FPLQSGILTM NPGIQGQPIL TSLKQSQEEA YVTMSSFYKN Q
//
