ID   G5CAE9_HETGA            Unreviewed;       959 AA.
AC   G5CAE9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Twinkle protein, mitochondrial {ECO:0000313|EMBL:EHB18510.1};
GN   ORFNames=GW7_15878 {ECO:0000313|EMBL:EHB18510.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18510.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB18510.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
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DR   EMBL; JH174169; EHB18510.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5CAE9; -.
DR   STRING; 10181.G5CAE9; -.
DR   eggNOG; KOG2373; Eukaryota.
DR   InParanoid; G5CAE9; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd01029; TOPRIM_primases; 1.
DR   CDD; cd01122; Twinkle_C; 2.
DR   Gene3D; 3.40.1360.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR   InterPro; IPR027032; Twinkle-like.
DR   PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR   PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR   Pfam; PF13481; AAA_25; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51199; SF4_HELICASE; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   DOMAIN          383..634
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   DOMAIN          659..910
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   REGION          918..959
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   959 AA;  108197 MW;  B80E9448BE2A06A9 CRC64;
     MWVLLRGAYP LRALLPLRGE WMGRRGLPRS LVPGPPRRRY RKEALPALEV SVLPVTTTEI
     RQYLRTRGIP FQDGHSCLRA PSPFEESSQV KDQTRATTSF SLFIDKTTGR FLCMTSLAEG
     SWEDFQASVE GRMDGVKQGV LLSEAPETEN SEEVRRIWDR AVPLWELPDS EEAQLARVMF
     GLTKVTDDTL RRFRVQYLRP ARSLVFPWFS QGSGLRGLKL LGAEGHGDGV HYMETTIPRP
     GAYHNLFGLP LISRRDVEVV LTSRELDSLA LSQATGLPTL ALPRGTLSLP PALLPYLEQF
     RRIILWLGDD LRSWEAAKLF ARKLNPKRCS LVRPGDQQPR PLEALNRGLN LSRILRTALP
     AWHKSIVSFR QLREEVLGEL TDVEQAAGIR WSRFPDLNRL LKGHRKGELT VFTGPTGSGK
     TTFISEYALD LCTQGVNTLW GSFEISNVRL ARVMLTQFAV GQLEEQLDKY DVWADRFEDL
     PLYVMTFHGQ QSIRFVIDTM QHAVYVYDVC HVVIDNLQFM MGHEQLSTDR IAAQDYIVGA
     FRKFATENNC HVTLVIHPRK EDDDKELQTA SIFGSAKASQ EADNILILQD RKLVTGPGKR
     YLQVSKNRFD GDVGVFPLEF NKSSLTFSIP PKSKTRLKKI KDDGGLVLRE EVLGELTDVE
     QAAGIRWSRF PDLNRLLKGH RKGELTVFTG PTGSGKTTFI SEYALDLCTQ GVNTLWGSFE
     ISNVRLARVM LTQFAVGRLE EQLDKYDEWA DRFEDLPLYF MTFHGQQSIR SVIDTMQHAV
     YVYDVCHVVI DNLQFMMGHE QLSTDRIAAQ DYIVGAFRKF ATENNCHVTL VIHPRKEDDD
     KELQTASIFG SAKASQEADN ILILQDRKLV TGPGKRYLQV SKNRFDGDVG VFPLEFNKSS
     LTFSIPPKSK TRLKKIKDDG GLVVKKPSSG KKGGVPQNCE TCPGQDPIPL QPDTSKPTG
//