ID G5CB80_HETGA Unreviewed; 377 AA.
AC G5CB80;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Cytoplasmic protein {ECO:0000256|PIRNR:PIRNR037874};
GN ORFNames=GW7_05142 {ECO:0000313|EMBL:EHB18791.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18791.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB18791.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}.
CC Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
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DR EMBL; JH204765; EHB18791.1; -; Genomic_DNA.
DR RefSeq; XP_004844548.1; XM_004844491.1.
DR AlphaFoldDB; G5CB80; -.
DR STRING; 10181.G5CB80; -.
DR Ensembl; ENSHGLT00100016305; ENSHGLP00100016128; ENSHGLG00100011905.
DR GeneID; 101720865; -.
DR KEGG; hgl:101720865; -.
DR CTD; 8440; -.
DR eggNOG; KOG4226; Eukaryota.
DR InParanoid; G5CB80; -.
DR OMA; TWYYGAI; -.
DR OrthoDB; 25798at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000009295; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd10409; SH2_Nck2; 1.
DR CDD; cd11899; SH3_Nck2_1; 1.
DR CDD; cd11902; SH3_Nck2_2; 1.
DR CDD; cd11903; SH3_Nck2_3; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR017304; NCK.
DR InterPro; IPR035883; Nck2_SH2.
DR InterPro; IPR035559; Nck2_SH3_1.
DR InterPro; IPR035560; Nck2_SH3_2.
DR InterPro; IPR035561; Nck2_SH3_3.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF12; CYTOPLASMIC PROTEIN NCK2; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PIRSF; PIRSF037874; Cytoplasmic_NCK; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037874};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Translation regulation {ECO:0000256|PIRNR:PIRNR037874}.
FT DOMAIN 2..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 110..169
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 192..254
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 282..376
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 79..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 42423 MW; DD2A31625F6F3E62 CRC64;
MTEEVIVIAK WDYTAQQEQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN
SLKKGSLVKN LKDTLGLGRT RRKPSARDAS PTPSTDAEFP ANGAADRIYD LSIPAFVKFA
YVAEREDELS LVKGSRVTVM EKCSDGWWRG SFNGQVGWFP SNYVLEEVDS AAAELPGMPG
PRRAPGLSLT RGTLHVVQTL YPFSSATEEE LNFDKGETME VIEKPENDPE WWKCKNARGQ
VGLVPKNYVM VLSDGPAPHP VPTSHPGFSG PSASGRFAGR EWYYGSVTRH QAECVLNERG
VEGDFLVRDS ESSPSDFSVS LKASGKNKHF KVQLVDNVYC IGQRRFHSMD ELVEHYKKAP
IFTSEHGEKL YLVRALQ
//
