ID AQP10_MILTA Reviewed; 409 AA.
AC G5CTG7;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Aquaporin-10 {ECO:0000303|PubMed:23761966};
DE Short=AQP-10 {ECO:0000303|PubMed:23761966};
GN Name=AQP10 {ECO:0000303|PubMed:23761966};
OS Milnesium tardigradum (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Apochela;
OC Milnesiidae; Milnesium.
OX NCBI_TaxID=46460;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, AND INDUCTION.
RX PubMed=23761966; DOI=10.4137/bbi.s11497;
RA Grohme M.A., Mali B., Welnicz W., Michel S., Schill R.O., Frohme M.;
RT "The aquaporin channel repertoire of the tardigrade Milnesium
RT tardigradum.";
RL Bioinf. Biol. Insights 7:153-165(2013).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND INDUCTION.
RX PubMed=23029181; DOI=10.1371/journal.pone.0045682;
RA Schokraie E., Warnken U., Hotz-Wagenblatt A., Grohme M.A., Hengherr S.,
RA Foerster F., Schill R.O., Frohme M., Dandekar T., Schnoelzer M.;
RT "Comparative proteome analysis of Milnesium tardigradum in early embryonic
RT state versus adults in active and anhydrobiotic state.";
RL PLoS ONE 7:E45682-E45682(2012).
CC -!- FUNCTION: Aquaglyceroporin that may modulate the water content and
CC osmolytes during anhydrobiosis (PubMed:23761966).
CC {ECO:0000305|PubMed:23761966}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expressed in early embryonic state, adult active, and adult
CC anhydrobiotic state (PubMed:23029181). Transcript abundance is high and
CC expression levels are not significantly affected by desiccation or
CC rehydratation (PubMed:23761966). {ECO:0000269|PubMed:23029181,
CC ECO:0000269|PubMed:23761966}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA). {ECO:0000305|PubMed:23761966}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
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DR EMBL; JN378745; AEP14564.1; -; mRNA.
DR AlphaFoldDB; G5CTG7; -.
DR SMR; G5CTG7; -.
DR GlyCosmos; G5CTG7; 1 site, No reported glycans.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0015791; P:polyol transmembrane transport; IEA:UniProt.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR43829; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR PANTHER; PTHR43829:SF9; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Repeat; Stress response;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..409
FT /note="Aquaporin-10"
FT /id="PRO_0000440211"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 164..166
FT /note="NPA 1"
FT MOTIF 297..299
FT /note="NPA 2"
FT COMPBIAS 47..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 409 AA; 44699 MW; 3F8833EB87477618 CRC64;
MADAPTYIRQ STTGTATTAP TTMPVHPDTT YYKTTTTTVS DAPRAIADVN DDNHDNYDET
TGLRSGEKKT RPLVTSTTAP IDAGRMTLGQ KISRWTRIGS DLAREALAEF LGSFILIVFG
NGVVAQVVLS RGAHGNFLSI NIGYGLAVAF GVYIAGGISG GHLNPAVSLA FAALGKLPWR
KLPVYMFAQY AGCICASAIV HAIYYDALNN YDGGNRTRGD TWQSTAGIHA SYPQEFLYWQ
TGLADQIFAT SFLMIGILAL TDNRNTGPPG GVVPILVGCL VMAIGLAYGF NCGYPINPAR
DMGPRLFTLM AGWGSRTFSN YNPYIFNDYY QRIPYWFWIP VVGPHLGALL GAAIYFFFIG
NHWPTLHRNV LELQVGHRDN SDDIELLAAK SRRPIEVVTT TETTRERRT
//
