ID G5E536_BOVIN Unreviewed; 533 AA.
AC G5E536;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=KPNA6 {ECO:0000313|Ensembl:ENSBTAP00000003764.6,
GN ECO:0000313|VGNC:VGNC:30705};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003764.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000003764.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003764.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000003764.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003764.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in nuclear protein import.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G5E536; -.
DR SMR; G5E536; -.
DR Ensembl; ENSBTAT00000003764.6; ENSBTAP00000003764.6; ENSBTAG00000002896.6.
DR VEuPathDB; HostDB:ENSBTAG00000002896; -.
DR VGNC; VGNC:30705; KPNA6.
DR GeneTree; ENSGT01050000244950; -.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; G5E536; -.
DR OMA; EMIQMLY; -.
DR TreeFam; TF354205; -.
DR Reactome; R-BTA-68616; Assembly of the ORC complex at the origin of replication.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000002896; Expressed in spermatid and 108 other cell types or tissues.
DR ExpressionAtlas; G5E536; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0043657; C:host cell; IEA:GOC.
DR GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0075506; P:entry of viral genome into host nucleus through nuclear pore complex via importin; IEA:Ensembl.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:1903902; P:positive regulation of viral life cycle; IEA:Ensembl.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF8; IMPORTIN SUBUNIT ALPHA-7; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..57
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 121..164
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 164..192
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 59520 MW; 7CD94E135CA2EDF5 CRC64;
MASPGKDNYR MKSYKNNALN PEEMRRRREE EGIQLRKQKR EQQLFKRRNV ELINEEAAMF
DSLLMDSYVS STTGESVITR EMVEMLFSDD PDLQLATTQK FRKLLSKEPS PPIDEVINTP
GVVDRFVEFL KRNENCTLQF EAAWALTNIA SGTSQQTKIV IEAGAVPIFI ELLNSDFEDV
QEQAVWALGN IAGDSSVCRD YVLNCSILNP LLTLLTKSTR LTMTRNAVWA LSNLCRGKNP
PPEFAKVSPC LPVLSRLLFS SDSDLLADAC WALSYLSDGP NEKIQAVIDS GVCRRLVELL
MHNDNKVASP ALRAVGNIVT GDDIQTQVIL NCSALPCLLH LLSSSKESIR KEACWTISNI
TAGNRAQIQA VIDANIFPVL IEILQKAEFR TRKEAAWAIT NATSGGTPEQ IRYLVSLGCI
KPLCDLLTVM DSKIVQVALN GLENILRLGE QEGKRSGSGV NPYCGLIEEA YGLDKIEFLQ
SHENQEIYQK AFDLIEHYFG VEDDDSSLAP QVDETQQQFI FQQPEAPMEG FQL
//
