ID   G5E543_BOVIN            Unreviewed;       343 AA.
AC   G5E543;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279, ECO:0000256|PIRNR:PIRNR000543};
GN   Name=NDUFA10 {ECO:0000313|Ensembl:ENSBTAP00000004245.6,
GN   ECO:0000313|VGNC:VGNC:59187};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000004245.6, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000004245.6, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004245.6,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000004245.6}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004245.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR000543}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|PIRNR:PIRNR000543};
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. This a
CC       component of the hydrophobic protein fraction.
CC       {ECO:0000256|ARBA:ARBA00011514}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000543}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC       {ECO:0000256|ARBA:ARBA00008606, ECO:0000256|PIRNR:PIRNR000543}.
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DR   AlphaFoldDB; G5E543; -.
DR   Ensembl; ENSBTAT00000004245.6; ENSBTAP00000004245.6; ENSBTAG00000003279.6.
DR   VEuPathDB; HostDB:ENSBTAG00000003279; -.
DR   VGNC; VGNC:59187; NDUFA10.
DR   GeneTree; ENSGT00390000016151; -.
DR   HOGENOM; CLU_050591_0_1_1; -.
DR   OMA; MFRQGYI; -.
DR   TreeFam; TF314616; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000003279; Expressed in laryngeal cartilage and 103 other cell types or tissues.
DR   ExpressionAtlas; G5E543; baseline and differential.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   CDD; cd02030; NDUO42; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR015828; NDUFA10.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW   ECO:0000256|PIRNR:PIRNR000543};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000543};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|PIRNR:PIRNR000543};
KW   Mitochondrion {ECO:0000256|PIRNR:PIRNR000543};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW   ECO:0000256|PIRNR:PIRNR000543};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR000543}.
FT   DOMAIN          48..235
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
SQ   SEQUENCE   343 AA;  39294 MW;  776FB06A6BD24709 CRC64;
     MALRLLRLVP PRVGGIHTSV QFKLQYGPLA YILGEKATKK MTEKSKLITV DGNICSGKSK
     LAKEIAEKLG LKHFPEAGIH YVDSTTGDGK PLPVQFSGNC SLEKFYDDPK SNDGNSYRLQ
     SWLYASRLLQ YADALEHLLS TGQGVVLERS IYSDFVFLEA MYRQGFIRKQ CVDHYNQVKK
     VTICEYLPPH VVVYVDVPVP EVQSRIQKKG NPHEMKITSA YLQDIENAYK GTFLPEMSEK
     CEVLQYSAWE AQDAEKVVED IEYLKYDKGP WLDQNDRKLH KLRMLVQDKL EVLNYTSIPV
     FLPEVTVGAH QSDQVFQEFT ELPGRKYRAG YNEDVGDKWI WLK
//