ID G5E5C4_BOVIN Unreviewed; 1874 AA.
AC G5E5C4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Programmed cell death 11 {ECO:0000313|Ensembl:ENSBTAP00000012818.6};
GN Name=PDCD11 {ECO:0000313|Ensembl:ENSBTAP00000012818.6,
GN ECO:0000313|VGNC:VGNC:32659};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000012818.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000012818.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012818.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000012818.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012818.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR SMR; G5E5C4; -.
DR Ensembl; ENSBTAT00000012818.6; ENSBTAP00000012818.6; ENSBTAG00000009715.6.
DR VEuPathDB; HostDB:ENSBTAG00000009715; -.
DR VGNC; VGNC:32659; PDCD11.
DR GeneTree; ENSGT00390000012228; -.
DR HOGENOM; CLU_000845_1_1_1; -.
DR InParanoid; G5E5C4; -.
DR OMA; GQYLRAY; -.
DR OrthoDB; 167902at2759; -.
DR TreeFam; TF105697; -.
DR Reactome; R-BTA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Proteomes; UP000009136; Chromosome 26.
DR Bgee; ENSBTAG00000009715; Expressed in spermatid and 107 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd05701; S1_Rrp5_repeat_hs10; 1.
DR CDD; cd05702; S1_Rrp5_repeat_hs11_sc8; 1.
DR CDD; cd05703; S1_Rrp5_repeat_hs12_sc9; 1.
DR CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR CDD; cd05694; S1_Rrp5_repeat_hs2_sc2; 1.
DR CDD; cd05695; S1_Rrp5_repeat_hs3; 1.
DR CDD; cd05696; S1_Rrp5_repeat_hs4; 1.
DR CDD; cd05697; S1_Rrp5_repeat_hs5; 1.
DR CDD; cd05698; S1_Rrp5_repeat_hs6_sc5; 1.
DR CDD; cd04461; S1_Rrp5_repeat_hs8_sc7; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 9.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR048058; Rrp5_S1_rpt_hs11_sc8.
DR InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR Pfam; PF00575; S1; 5.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 7.
DR SMART; SM00316; S1; 13.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 10.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50126; S1; 12.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 83..171
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 187..258
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 281..346
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 365..436
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 453..522
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 542..611
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 634..705
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 727..796
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1034..1107
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1148..1222
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1230..1298
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1324..1396
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1404..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1557..1589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1874 AA; 208571 MW; D3A0B5B08504C68C CRC64;
MAAMEESFPR GGTRKTHKSE KAFQQSVEQD NLFDISTEEE STKRKKIQKG PAKTKKLKVE
TRQSSKFVRE KFEILNVESL CEGMRILGCV KEVNELELAI SLPNGLQGYV QVTEICDAYT
EKLNEQVAQE EPLQDLVGLP ELFSPGMLVR CVVSSLDTTK GSKKNVMLSL NPKNVNRVLS
AETLKPGMLL TGTVSSLEDH GYLVDIGVSG ARAFLPLQKA QEYIRQKNKG AKLKVGQYLN
CLIEEVKGSR GVVTLSIGHS EVSAAIATEE QSWTLNSLLP GLVVKAQVQK VTPLGLTLKF
LSFFSGLVDF MHLDPKKAGT YFSNQQVRAC VLCVHPRTRA VRLSLRPVFL QPGRPLTRLL
CQQLGAVLDD VPVQGFFGSA GATFKLKDGT LAYARRNHLS NSKKTFKPEA FKPGNTHKCR
IIDYSQMDEL ALLSLRTSII EAQFLWYHDI KPGALVKGKV LTIKPHGMVV KMGKQIRGLV
PTMHLADILI KNPEKKYHVG DEVKCRVLLC DPKAKKLMMT LKKTLVESKL PAITCYDDAK
PGLQTHGFIL RVKDYGCIVK FYNDVQGLVP RHELSAEYVP DPESVFYTGQ VVKVVVLNCE
PSKERMLLSF RLLSDPKQEG EGQSQKKKKA VSAGQLVDVK VLEKTKDGLK VAVLPHNIPG
FLPTAHLSDH VTNGPLLYHW LQTGDTLHRV LCLSVSEERV LLCRKPALVS AVEGGQNPKS
FSEIHPGMLL IGFVKNIKDY GVFVQFPSGL SGLAPKAILS DKFVTSTSDH FVEGQTVVAK
VTNVDEEKQR MLLSLRLSDC TLGDLATTSL LLLSQCLEER QGVRSLMSNR DSVLIQTLAE
MTPGMALDLE VQEVLEDGSV LFSEGPVPGL VLRASKYHRA GQELEPGQKK KAVILNVDML
KLEVHVSLCH DLVNRKAKKL KKGSDLQAIV QHLEESFAVA SLVETGHLAA FSLTSHLNDT
FRFDSEKLQV GQGVSLTLQT TEPGVTGLLL AIEGPAAKRT MRQTRKDSET VDEDEEVDPA
LVVGTVKKHT LSIGDVVTGT VKSIKPTHVV VTLEDGIIGC IHASHILDDV PVGTSPTAKL
KVGKKVTARV IGGRDMKTFK FLPISHPRFI RTIPELSVRP SELKEDGHTT LNTHSVSPLE
KIKQYQPGQT VTCFLKKYNM VKKWLEVEIA PDIRGRIPLL LTSLSFKVLK HPDKKFQIGQ
ALKATVVGPA ESSKAFLCLS LIGPHKLKKG EVAMGRVVKV TPKEGLTVSF PFGRVGRVSM
FHVSDSYSET HLEDFVPQQV VRCYVLSAAT PVLTLSLRSS RTNPETKSKI TDPEINSIED
LEEGQLLRGF VKSVQPSGVL VGLGPSVTGL ARHPHVSQHN QSKNAPYDRH LPEGKLLTAK
VLRLNHQESL VELSLLPDAT GKQDVLSAPL GQPPPKQEGR ETEAVERNHE GKAKEKKKQK
QKEKRTGKGQ EGAQPPSKDK KEPQKPQAKK LGKRPHPESS SEQEIGNKKQ KKAALSEEDD
SGVEVYYREG EEAEEMSMLP KEKLTRPAEA PRLQLSSGFV WDVGLDTLTP ALPPHGDSSD
SEEDEKPEQA TQKKKSKKER ELEKQKAEKE LSRIEEALMD PGRQPESAED FDRLVLSSPS
SSLLWLQYMA FHLQATEIEK ARAVAERALK TISFREEQEK LNVWVALLNL ENMYGSQESL
TKVFERAVQY NEPLKVFLHL ADIYTKSEKF QEAGELYNRM LKRFRQEKAV WVKYGAFLLR
RGKAEASHRV MQRALECLPK KEHVDVIAKF AQLEFQLGDA ERARAIFEST LSIYPKRTDV
WSVYIDMIIK HGSQKEARAI FERVIHLSLA PKRMKFFFKR YLDYEKQHGS EKDVQAVKAK
ALEYVEAKSS MMDD
//
