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Database: UniProt
Entry: G5E5K0_BOVIN
LinkDB: G5E5K0_BOVIN
Original site: G5E5K0_BOVIN 
ID   G5E5K0_BOVIN            Unreviewed;       452 AA.
AC   G5E5K0;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   31-JUL-2019, entry version 57.
DE   SubName: Full=Glycine receptor alpha 2 {ECO:0000313|Ensembl:ENSBTAP00000022869};
GN   Name=GLRA2 {ECO:0000313|Ensembl:ENSBTAP00000022869,
GN   ECO:0000313|VGNC:VGNC:29413};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000022869, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000022869, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022869,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000022869}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022869};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   RefSeq; NP_001179843.1; NM_001192914.1.
DR   SMR; G5E5K0; -.
DR   STRING; 9913.ENSBTAP00000022869; -.
DR   PaxDb; G5E5K0; -.
DR   Ensembl; ENSBTAT00000022869; ENSBTAP00000022869; ENSBTAG00000017209.
DR   GeneID; 537660; -.
DR   KEGG; bta:537660; -.
DR   CTD; 2742; -.
DR   VGNC; VGNC:29413; GLRA2.
DR   eggNOG; KOG3643; Eukaryota.
DR   eggNOG; ENOG410XPWH; LUCA.
DR   GeneTree; ENSGT00940000158730; -.
DR   InParanoid; G5E5K0; -.
DR   KO; K05194; -.
DR   OMA; AFFNLAY; -.
DR   OrthoDB; 614790at2759; -.
DR   TreeFam; TF315453; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000017209; Expressed in 1 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0098690; C:glycinergic synapse; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0016934; F:extracellularly glycine-gated chloride channel activity; IEA:Ensembl.
DR   GO; GO:0016594; F:glycine binding; IEA:Ensembl.
DR   GO; GO:0022852; F:glycine-gated chloride ion channel activity; IEA:Ensembl.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IEA:Ensembl.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0071294; P:cellular response to zinc ion; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0043200; P:response to amino acid; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0060012; P:synaptic transmission, glycinergic; IBA:GO_Central.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR008127; Glycine_rcpt_A.
DR   InterPro; IPR008129; Glycine_rcpt_A2.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   PANTHER; PTHR18945:SF28; PTHR18945:SF28; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR01673; GLYRALPHA.
DR   PRINTS; PR01675; GLYRALPHA2.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR608127-52,
KW   ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    452       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003475746.
FT   TRANSMEM    254    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    283    299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    319    342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    424    444       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       47    254       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      261    347       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   SITE        295    295       Important for obstruction of the ion pore
FT                                in the closed conformation.
FT                                {ECO:0000256|PIRSR:PIRSR608127-51}.
FT   DISULFID    172    186       {ECO:0000256|PIRSR:PIRSR608127-52}.
FT   DISULFID    232    243       {ECO:0000256|PIRSR:PIRSR608127-52}.
SQ   SEQUENCE   452 AA;  52009 MW;  2980B1FDBA1310D7 CRC64;
     MNRQLVSILT TLFAFFLETN HFRAAFCKDH DSRSGKQPSQ TLSPSDFLDK LMGRTSGYDA
     RIRPNFKGPP VNVTCNIFIN SFGSIAETTM DYRVNIFLRQ QWNDSRLAYS EYPDDSLDLD
     PSMLDSIWKP DLFFANEKGA NFHDVTTDNK LLRISKNGKV LYSIRLTLTL SCPMDLKNFP
     MDVQTCTMQL ESFGYTMNDL IFEWLSDGPV QVAEGLTLPQ FILKEEKELG YCTKHYNTGK
     FTCIEVKFHL ERQMGYYLIQ MYIPSLLIVI LSWVSFWINM DAAPARVALG ITTVLTMTTQ
     SSGSRASLPK VSYVKAIDIW MAVCLLFVFA ALLEYAAVNF VSRQHKEFLR LRRRQKRQNK
     EEDVTRESRF NFSGYGMGQC LQVKDGTAVK ATPANQLPQP PKDADAIKKK FVDRAKRIDT
     ISRAAFPLAF LIFNIFYWIT YKIIRHEDIH KK
//
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