ID G5E6L1_BOVIN Unreviewed; 634 AA.
AC G5E6L1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A19 {ECO:0000313|Ensembl:ENSBTAP00000055648.2,
GN ECO:0000313|VGNC:VGNC:34919};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055648.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055648.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055648.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055648.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055648.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR AlphaFoldDB; G5E6L1; -.
DR STRING; 9913.ENSBTAP00000055648; -.
DR PaxDb; 9913-ENSBTAP00000055648; -.
DR Ensembl; ENSBTAT00000064818.2; ENSBTAP00000055648.2; ENSBTAG00000045695.2.
DR VEuPathDB; HostDB:ENSBTAG00000045695; -.
DR VGNC; VGNC:34919; SLC6A19.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000154896; -.
DR HOGENOM; CLU_006855_7_2_1; -.
DR InParanoid; G5E6L1; -.
DR OMA; WPKELIT; -.
DR OrthoDB; 3084493at2759; -.
DR TreeFam; TF343812; -.
DR Reactome; R-BTA-352230; Amino acid transport across the plasma membrane.
DR Reactome; R-BTA-442660; Na+/Cl- dependent neurotransmitter transporters.
DR Proteomes; UP000009136; Chromosome 20.
DR Bgee; ENSBTAG00000045695; Expressed in cortex of kidney and 23 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0015175; F:neutral L-amino acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002438; Neutral_aa_SLC6.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF125; SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01206; ORPHTRNSPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 634 AA; 71163 MW; 973605DEEBC56F7B CRC64;
MVRLALPNPG LEARIPSLGE LERVEREESS SRPTWDNKAQ YMLTCVGFCV GLGNVWRFPY
LCQSHGGGAF MIPFLILLVL EGIPLLHLEF AIGQRLRKGS VGVWSAIHPA LKGVGIASMF
VSFMVGLYYN TIIAWVMWYF FNSFQEPLPW SQCPLNANQT GYVDECARSS SVDYFWYRET
LNVSTSIDDS GSVQWWILLA LTCAWSVLYV CTIRGIETTG KAVYITSTLP YVVLTIFLIR
GLTLKGATNG IVFLFTPNVT ELANPVTWLD AGAQVFYSFS LAFGGLISFS SYNPVHNNCE
MDSVIVSVIN GFTSVYAATV VYSIIGFRAT ERYDDCFSTN ILTLINGFDL PEGNVTQENF
AEMQRWCNAS DPAAYARLKF QTCDMDAFLS QGVEGTGLAF IVFTEAITKM PVAPLWSVLF
FVMLFCLGLS SMFGNMEGVV VPLQDLKVIP KKWPKELLTG LICLGMYLIA FIFTLNSGQY
WLSLLDSYAG SIPLLVIAFF EMFSVVYVYG VDRFNRDIEF MIGHKPNIFW QVTWRVVSPL
LMLAIFLFFF VIEVREELTY NIWDPAYEEF PKSKEIKYPG WVYAVVVLVA GVPCLVIPGF
AIYKLIRNHF QRRGDQRALV SSLSAASVNG GLWS
//
