ID G5E6T5_BOVIN Unreviewed; 126 AA.
AC G5E6T5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Histone H2A/H2B/H3 domain-containing protein {ECO:0000259|Pfam:PF00125};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056498.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000056498.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056498.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000056498.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056498.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the histone H2B family.
CC {ECO:0000256|ARBA:ARBA00006846}.
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DR AlphaFoldDB; G5E6T5; -.
DR SMR; G5E6T5; -.
DR STRING; 9913.ENSBTAP00000056498; -.
DR PaxDb; 9913-ENSBTAP00000056498; -.
DR Ensembl; ENSBTAT00000063293.2; ENSBTAP00000056498.1; ENSBTAG00000047978.2.
DR VEuPathDB; HostDB:ENSBTAG00000047978; -.
DR eggNOG; KOG1744; Eukaryota.
DR GeneTree; ENSGT01100000263474; -.
DR HOGENOM; CLU_075666_2_1_1; -.
DR InParanoid; G5E6T5; -.
DR TreeFam; TF300212; -.
DR Reactome; R-BTA-110330; Recognition and association of DNA glycosylase with site containing an affected purine.
DR Reactome; R-BTA-110331; Cleavage of the damaged purine.
DR Reactome; R-BTA-171306; Packaging Of Telomere Ends.
DR Reactome; R-BTA-201722; Formation of the beta-catenin:TCF transactivating complex.
DR Reactome; R-BTA-212300; PRC2 methylates histones and DNA.
DR Reactome; R-BTA-2299718; Condensation of Prophase Chromosomes.
DR Reactome; R-BTA-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-BTA-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-BTA-2559586; DNA Damage/Telomere Stress Induced Senescence.
DR Reactome; R-BTA-3214815; HDACs deacetylate histones.
DR Reactome; R-BTA-3214847; HATs acetylate histones.
DR Reactome; R-BTA-427359; SIRT1 negatively regulates rRNA expression.
DR Reactome; R-BTA-427413; NoRC negatively regulates rRNA expression.
DR Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-BTA-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-BTA-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
DR Reactome; R-BTA-5689880; Ub-specific processing proteases.
DR Reactome; R-BTA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR Reactome; R-BTA-5693571; Nonhomologous End-Joining (NHEJ).
DR Reactome; R-BTA-5693607; Processing of DNA double-strand break ends.
DR Reactome; R-BTA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR Reactome; R-BTA-68616; Assembly of the ORC complex at the origin of replication.
DR Reactome; R-BTA-69473; G2/M DNA damage checkpoint.
DR Reactome; R-BTA-73728; RNA Polymerase I Promoter Opening.
DR Reactome; R-BTA-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-BTA-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-BTA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR Reactome; R-BTA-9018519; Estrogen-dependent gene expression.
DR Reactome; R-BTA-9670095; Inhibition of DNA recombination at telomere.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000047978; Expressed in placenta and 12 other cell types or tissues.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; HISTONE H2B; 1.
DR PANTHER; PTHR23428:SF250; HISTONE H2B TYPE 1-H; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00621; HISTONEH2B.
DR SMART; SM00427; H2B; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 15..101
FT /note="Histone H2A/H2B/H3"
FT /evidence="ECO:0000259|Pfam:PF00125"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 126 AA; 13820 MW; 372852ECA25AD23B CRC64;
MPEQAKSAPA PKNGSKKAVT KAQKKDGKKP KRSHRESYSM DVYKVLKQVY LDTSISSKAM
GIMNSFVNDI FEGIAGEAWH LAHYNKHSTV TSREIQTALR LLLPGGLAKH AVSEGTEAVT
KYTSSK
//
