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Database: UniProt
Entry: G5E8I8_MOUSE
LinkDB: G5E8I8_MOUSE
Original site: G5E8I8_MOUSE 
ID   G5E8I8_MOUSE            Unreviewed;       949 AA.
AC   G5E8I8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   24-JAN-2024, entry version 90.
DE   SubName: Full=Calcium homeostasis endoplasmic reticulum protein {ECO:0000313|Ensembl:ENSMUSP00000078469.6};
GN   Name=Cherp {ECO:0000313|Ensembl:ENSMUSP00000078469.6,
GN   ECO:0000313|MGI:MGI:106417};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000078469.6, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:17947660}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17947660;
RA   Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA   Kawakami T., Salomon A.R.;
RT   "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT   signaling.";
RL   J. Immunol. 179:5864-5876(2007).
RN   [2] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [3] {ECO:0007829|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000078469.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078469.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000078469.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078469.6};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_006509748.1; XM_006509685.3.
DR   AlphaFoldDB; G5E8I8; -.
DR   SMR; G5E8I8; -.
DR   SwissPalm; G5E8I8; -.
DR   jPOST; G5E8I8; -.
DR   PeptideAtlas; G5E8I8; -.
DR   ProteomicsDB; 347020; -.
DR   Antibodypedia; 27406; 256 antibodies from 30 providers.
DR   Ensembl; ENSMUST00000079510.6; ENSMUSP00000078469.6; ENSMUSG00000052488.8.
DR   UCSC; uc009mga.1; mouse.
DR   AGR; MGI:106417; -.
DR   MGI; MGI:106417; Cherp.
DR   VEuPathDB; HostDB:ENSMUSG00000052488; -.
DR   GeneTree; ENSGT00730000111147; -.
DR   HOGENOM; CLU_009446_0_0_1; -.
DR   OrthoDB; 1220847at2759; -.
DR   PhylomeDB; G5E8I8; -.
DR   TreeFam; TF318512; -.
DR   BioGRID-ORCS; 27967; 22 hits in 77 CRISPR screens.
DR   ChiTaRS; Cherp; mouse.
DR   Proteomes; UP000000589; Chromosome 8.
DR   Bgee; ENSMUSG00000052488; Expressed in gonadal ridge and 259 other cell types or tissues.
DR   ExpressionAtlas; G5E8I8; baseline and differential.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.10.10.790; Surp module; 1.
DR   InterPro; IPR039037; CHERP.
DR   InterPro; IPR006569; CID_dom.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR000061; Surp.
DR   InterPro; IPR035967; SWAP/Surp_sf.
DR   PANTHER; PTHR12323:SF0; CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN; 1.
DR   PANTHER; PTHR12323; SR-RELATED CTD ASSOCIATED FACTOR 6; 1.
DR   Pfam; PF04818; CID; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF01805; Surp; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00648; SWAP; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109905; Surp module (SWAP domain); 1.
DR   PROSITE; PS51391; CID; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50128; SURP; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:G5E8I8,
KW   ECO:0007829|MaxQB:G5E8I8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          15..57
FT                   /note="SURP motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50128"
FT   DOMAIN          149..300
FT                   /note="CID"
FT                   /evidence="ECO:0000259|PROSITE:PS51391"
FT   DOMAIN          863..913
FT                   /note="G-patch"
FT                   /evidence="ECO:0000259|PROSITE:PS50174"
FT   REGION          77..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..93
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..399
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..470
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..517
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..555
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..641
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..838
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   949 AA;  107671 MW;  9E4884EB3F4BD213 CRC64;
     MEMPMPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG EFYSYYKCKL
     ALEQQQLICK QQAPELEPTS AMPPLPQPPL APTASLTPAQ GTPSMDELIQ QSQWSLQQQE
     QHLLALRQEQ VTTAVAHAVE QQMQKLLEET QLDMSEFDNL LQPIIDTCTK DAISAGKNWM
     FSNAKSPPHC ELMAGHLRNR ITADGAHFEL RLHLIYLIND VLHHWALTRG RSLPHSQRKQ
     ARELLAALQK VVVPIYCTSF LAVEEDKQQK IARLLQLWEK NGYFDDSIIQ QLQSPALGLG
     QYQATLINEY SSVVQPVQLA FQQQIQSLKT QHEEFVSSLA QQQQQQQQQQ QQQPQPQPQP
     QIQLPQMEAD VKATPPPPAP PPASAPAPTI PPTTQPDDNK PPIQMPGSSE YDTSAGVQDP
     AAAGPRGPGP HEQIPPNKPP WFDQPHPVAP WGQQQPPEQP PYPHHQGGPP HCPPWNNSHE
     GMWGEQRGDP GWNGQRDAPW NNQPDPNWNN QFEGPWNNQH EPPPWGGAQR EPPFRMQRPP
     HFRGPFPPHQ QHPQFNQPPH PHNFNRFPPR FMQDDFPPRH PFERPPYPHR FDYPQGDFPA
     DMGPPHHHPG HRMPHPGINE HPPWAGPQHP DFGPPPHGFN GQPPHMRRQG PPHINHDDPS
     LVPNVPYFDL PAGLMAPLVK LEDHEYKPLD PKDIRLPPPM PPSERLLAAV EAFYSPPSHD
     RPRNSEGWEQ NGLYEFFRAK MRARRRKGQE KRNSGPSRSR SRSKSRGRSS SRSSSRSSKS
     SRSSSRSHSR SRSRSSSRSR SRSRSRSRSS RSRSRSRSRS RSRSKSYSPG RRRRSRSRSP
     TPPSAAGLGS NSAPPIPDSR LGEENKGHQM LVKMGWSGSG GLGAKEQGIQ DPIKGGDVRD
     KWDQYKGVGV ALDDPYENYR RNKSYSFIAR MKARDEFSTF GTRKEEKED
//
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