ID G5E8I8_MOUSE Unreviewed; 949 AA.
AC G5E8I8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 24-JAN-2024, entry version 90.
DE SubName: Full=Calcium homeostasis endoplasmic reticulum protein {ECO:0000313|Ensembl:ENSMUSP00000078469.6};
GN Name=Cherp {ECO:0000313|Ensembl:ENSMUSP00000078469.6,
GN ECO:0000313|MGI:MGI:106417};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000078469.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17947660}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17947660;
RA Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA Kawakami T., Salomon A.R.;
RT "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT signaling.";
RL J. Immunol. 179:5864-5876(2007).
RN [2] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000078469.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078469.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000078469.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078469.6};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_006509748.1; XM_006509685.3.
DR AlphaFoldDB; G5E8I8; -.
DR SMR; G5E8I8; -.
DR SwissPalm; G5E8I8; -.
DR jPOST; G5E8I8; -.
DR PeptideAtlas; G5E8I8; -.
DR ProteomicsDB; 347020; -.
DR Antibodypedia; 27406; 256 antibodies from 30 providers.
DR Ensembl; ENSMUST00000079510.6; ENSMUSP00000078469.6; ENSMUSG00000052488.8.
DR UCSC; uc009mga.1; mouse.
DR AGR; MGI:106417; -.
DR MGI; MGI:106417; Cherp.
DR VEuPathDB; HostDB:ENSMUSG00000052488; -.
DR GeneTree; ENSGT00730000111147; -.
DR HOGENOM; CLU_009446_0_0_1; -.
DR OrthoDB; 1220847at2759; -.
DR PhylomeDB; G5E8I8; -.
DR TreeFam; TF318512; -.
DR BioGRID-ORCS; 27967; 22 hits in 77 CRISPR screens.
DR ChiTaRS; Cherp; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000052488; Expressed in gonadal ridge and 259 other cell types or tissues.
DR ExpressionAtlas; G5E8I8; baseline and differential.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.10.10.790; Surp module; 1.
DR InterPro; IPR039037; CHERP.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR000061; Surp.
DR InterPro; IPR035967; SWAP/Surp_sf.
DR PANTHER; PTHR12323:SF0; CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN; 1.
DR PANTHER; PTHR12323; SR-RELATED CTD ASSOCIATED FACTOR 6; 1.
DR Pfam; PF04818; CID; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF01805; Surp; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00648; SWAP; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109905; Surp module (SWAP domain); 1.
DR PROSITE; PS51391; CID; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50128; SURP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:G5E8I8,
KW ECO:0007829|MaxQB:G5E8I8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 15..57
FT /note="SURP motif"
FT /evidence="ECO:0000259|PROSITE:PS50128"
FT DOMAIN 149..300
FT /note="CID"
FT /evidence="ECO:0000259|PROSITE:PS51391"
FT DOMAIN 863..913
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 77..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..399
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..470
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..555
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..641
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..838
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 949 AA; 107671 MW; 9E4884EB3F4BD213 CRC64;
MEMPMPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG EFYSYYKCKL
ALEQQQLICK QQAPELEPTS AMPPLPQPPL APTASLTPAQ GTPSMDELIQ QSQWSLQQQE
QHLLALRQEQ VTTAVAHAVE QQMQKLLEET QLDMSEFDNL LQPIIDTCTK DAISAGKNWM
FSNAKSPPHC ELMAGHLRNR ITADGAHFEL RLHLIYLIND VLHHWALTRG RSLPHSQRKQ
ARELLAALQK VVVPIYCTSF LAVEEDKQQK IARLLQLWEK NGYFDDSIIQ QLQSPALGLG
QYQATLINEY SSVVQPVQLA FQQQIQSLKT QHEEFVSSLA QQQQQQQQQQ QQQPQPQPQP
QIQLPQMEAD VKATPPPPAP PPASAPAPTI PPTTQPDDNK PPIQMPGSSE YDTSAGVQDP
AAAGPRGPGP HEQIPPNKPP WFDQPHPVAP WGQQQPPEQP PYPHHQGGPP HCPPWNNSHE
GMWGEQRGDP GWNGQRDAPW NNQPDPNWNN QFEGPWNNQH EPPPWGGAQR EPPFRMQRPP
HFRGPFPPHQ QHPQFNQPPH PHNFNRFPPR FMQDDFPPRH PFERPPYPHR FDYPQGDFPA
DMGPPHHHPG HRMPHPGINE HPPWAGPQHP DFGPPPHGFN GQPPHMRRQG PPHINHDDPS
LVPNVPYFDL PAGLMAPLVK LEDHEYKPLD PKDIRLPPPM PPSERLLAAV EAFYSPPSHD
RPRNSEGWEQ NGLYEFFRAK MRARRRKGQE KRNSGPSRSR SRSKSRGRSS SRSSSRSSKS
SRSSSRSHSR SRSRSSSRSR SRSRSRSRSS RSRSRSRSRS RSRSKSYSPG RRRRSRSRSP
TPPSAAGLGS NSAPPIPDSR LGEENKGHQM LVKMGWSGSG GLGAKEQGIQ DPIKGGDVRD
KWDQYKGVGV ALDDPYENYR RNKSYSFIAR MKARDEFSTF GTRKEEKED
//