ID G5E8L3_MOUSE Unreviewed; 226 AA.
AC G5E8L3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=N-acetyltransferase 8 (GCN5-related) family member 4 {ECO:0000313|Ensembl:ENSMUSP00000093430.4};
GN Name=Nat8f4 {ECO:0000313|Ensembl:ENSMUSP00000093430.4,
GN ECO:0000313|MGI:MGI:1922791};
GN Synonyms=1700019G17Rik {ECO:0000313|MGI:MGI:1922791};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000093430.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000093430.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000093430.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000093430.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000093430.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the camello family.
CC {ECO:0000256|ARBA:ARBA00038470}.
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DR RefSeq; NP_083607.3; NM_029331.3.
DR RefSeq; XP_006506780.1; XM_006506717.3.
DR RefSeq; XP_006506783.1; XM_006506720.3.
DR RefSeq; XP_011239799.1; XM_011241497.2.
DR RefSeq; XP_017177305.1; XM_017321816.1.
DR AlphaFoldDB; G5E8L3; -.
DR STRING; 10090.ENSMUSP00000093430; -.
DR jPOST; G5E8L3; -.
DR MaxQB; G5E8L3; -.
DR PaxDb; 10090-ENSMUSP00000093430; -.
DR PeptideAtlas; G5E8L3; -.
DR ProteomicsDB; 334648; -.
DR DNASU; 75541; -.
DR Ensembl; ENSMUST00000095757.4; ENSMUSP00000093430.4; ENSMUSG00000068299.12.
DR GeneID; 75541; -.
DR UCSC; uc009cqj.2; mouse.
DR AGR; MGI:1922791; -.
DR CTD; 75541; -.
DR MGI; MGI:1922791; Nat8f4.
DR VEuPathDB; HostDB:ENSMUSG00000068299; -.
DR eggNOG; KOG3139; Eukaryota.
DR GeneTree; ENSGT00950000182932; -.
DR HOGENOM; CLU_013985_10_1_1; -.
DR InParanoid; G5E8L3; -.
DR OMA; LHYQYNI; -.
DR OrthoDB; 74682at2759; -.
DR PhylomeDB; G5E8L3; -.
DR TreeFam; TF324687; -.
DR BioGRID-ORCS; 75541; 4 hits in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; G5E8L3; Protein.
DR Bgee; ENSMUSG00000068299; Expressed in intestinal villus and 164 other cell types or tissues.
DR ExpressionAtlas; G5E8L3; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:MGI.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISO:MGI.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0047198; F:cysteine-S-conjugate N-acetyltransferase activity; ISO:MGI.
DR GO; GO:0004468; F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; ISO:MGI.
DR GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR13947; GNAT FAMILY N-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR13947:SF6; N-ACETYLTRANSFERASE 8 (GCN5-RELATED) FAMILY MEMBER 4-RELATED; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51186; GNAT; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:G5E8L3,
KW ECO:0007829|ProteomicsDB:G5E8L3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..221
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
SQ SEQUENCE 226 AA; 25500 MW; A73ED0737E025215 CRC64;
MAFYHIRQYQ EKDHKKVLEL FSRGMKEHVP AAFHHMLTLP QTLLLLPGVP VTIVLVSGSW
LLATVCSFLF LLCLRLLIWL SWRNYVATSL QADLADITKS YLNAHGSFWV AESGDQVVGI
VGARPVKDPP LGKKQMQLFR LSVSSQHRGQ GIAKALVRTV LWFARDQDYS DVVLETSCVQ
YSAVALYQAM GFRKTDQYFV SIATRLMGLS ILHFTYSLPF AWGSGM
//
