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Database: UniProt
Entry: G5EBV8_CAEEL
LinkDB: G5EBV8_CAEEL
Original site: G5EBV8_CAEEL 
ID   G5EBV8_CAEEL            Unreviewed;       937 AA.
AC   G5EBV8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   20-JUN-2018, entry version 69.
DE   SubName: Full=Olfactory channel {ECO:0000313|EMBL:AAB87064.1};
GN   Name=osm-9 {ECO:0000313|EMBL:CCD61335.1,
GN   ECO:0000313|WormBase:B0212.5};
GN   ORFNames=B0212.5 {ECO:0000313|WormBase:B0212.5}, CELE_B0212.5
GN   {ECO:0000313|EMBL:CCD61335.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:AAB87064.1};
RN   [1] {ECO:0000313|EMBL:AAB87064.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9334401;
RA   Colbert H.A., Smith T.L., Bargmann C.I.;
RT   "OSM-9, a novel protein with structural similarity to channels, is
RT   required for olfaction, mechanosensation, and olfactory adaptation in
RT   Caenorhabditis elegans.";
RL   J. Neurosci. 17:8259-8269(1997).
RN   [2] {ECO:0000313|EMBL:CCD61335.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61335.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000313|EMBL:CCD61335.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61335.1};
RA   Alber B.E., Fuchs G.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CCD61335.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61335.1};
RG   WormBase Consortium;
RA   WormBase;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; AF031408; AAB87064.1; -; mRNA.
DR   EMBL; BX284604; CCD61335.1; -; Genomic_DNA.
DR   PIR; D88651; D88651.
DR   PIR; T37241; T37241.
DR   RefSeq; NP_500372.1; NM_067971.3.
DR   UniGene; Cel.19680; -.
DR   STRING; 6239.B0212.5; -.
DR   EnsemblMetazoa; B0212.5; B0212.5; WBGene00003889.
DR   GeneID; 177117; -.
DR   KEGG; cel:CELE_B0212.5; -.
DR   CTD; 177117; -.
DR   WormBase; B0212.5; CE20445; WBGene00003889; osm-9.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   GeneTree; ENSGT00550000074425; -.
DR   KO; K04975; -.
DR   OMA; SEKEWVK; -.
DR   OrthoDB; EOG091G0250; -.
DR   Reactome; R-CEL-3295583; TRP channels.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00003889; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR   GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
DR   GO; GO:0005262; F:calcium channel activity; IMP:WormBase.
DR   GO; GO:0005261; F:cation channel activity; TAS:WormBase.
DR   GO; GO:0006972; P:hyperosmotic response; IMP:WormBase.
DR   GO; GO:0022401; P:negative adaptation of signaling pathway; IMP:WormBase.
DR   GO; GO:0042048; P:olfactory behavior; IMP:WormBase.
DR   GO; GO:0008355; P:olfactory learning; IMP:WormBase.
DR   GO; GO:0009612; P:response to mechanical stimulus; IMP:WormBase.
DR   GO; GO:0007608; P:sensory perception of smell; IMP:WormBase.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|SAAS:SAAS00790162};
KW   Ion transport {ECO:0000256|SAAS:SAAS00790154};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00788392}.
FT   TRANSMEM    391    409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    469    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    537    558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    622    641       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      171    318       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      171    203       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      227    259       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   937 AA;  106848 MW;  1798CB866E814A3A CRC64;
     MGGGSSRNKT EPRGEGVKLA FDPDEKWSNL YREREKNHLY KWVAVRKGGE LINIYERDGE
     EGVLKFAEEK LLTILYDEGQ NPKLVTYSDY IKWKKGVNVQ LGLSEESVDM QQSRFKEHYA
     LWKLNKRGVE GENLIHLLLN REQQVCYEIA RILLKRFPGM ANDIYLGDEQ FGQSALHLAI
     VHDDYETVSL LLNSKADVNA RACGNFFLPE DFKLTNKITD YQGYAYYGEY PLAFAACFGN
     KDIYDLLIQF GANPNLQDSF GNTILHMCVI NYSSSMYSYA VRHWAKPADP HVVNHAGFTP
     LTLATKLGRK QIFEEMLEIM KVEFWRFSDM TCSAYPLNTL DTIQPDGSTN YDSALMTVIN
     GSTPEHLDMI GSEVIQRLLA DKWKAFAQRK LIERLVLLIV QLITLSIVVY IRPTELPRLY
     MEDPQWDDYI RTACELLTIL NCIFFVGYQQ LGEIRTQGMR GYLRNLKTAP AKAVFCIANL
     FLLLCIPFRL MKKHEIEEAL FVFALPGSWI FLLFFARSAK LTGPFVQMIY SMIAGDMIRF
     AIISAIFLVS FSQVFYFVGK DMDAKQKLED TNPHACRISG YTIYTYNTFP ETFITLFRAS
     MGGYDYEEFS CANYQALTKT LFVLYMFVMP IMMINILIAM MGNTYTTVIA QAEKAWRQQY
     AQIVMVLERS VGKERLAASQ LEYSIRLDQE GSSGMEVRGL MVIKQTKKTR ARQRKQAIYN
     WKTIGRKVIH TIDKVGTEQA VLLLHGHDRL DRVYEDHVQP EKVPSRSRTP TRIGTTLNSS
     KRLKTTTMVV GAAVTNTHEV RTDEAVNSML LSAPPSLSGE GATMDWQPSI TPVEERSESK
     SQEDRSEAST PNLGIHRTTP KADSPIRVVE YSRTIRVRAA DTIPSIELPN IPTKQTSSTP
     PHRAVSPRLR ADMFRRHQQP ASFDQSPPLP PTNDKSE
//
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