ID G5EBV9_CAEEL Unreviewed; 384 AA.
AC G5EBV9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Low-density lipoprotein receptor-related protein 2 {ECO:0000313|EMBL:CAB05479.2};
GN ORFNames=CELE_F09B12.5 {ECO:0000313|EMBL:CAB05479.2}, F09B12.5
GN {ECO:0000313|EMBL:CAB05479.2, ECO:0000313|WormBase:F09B12.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB05479.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB05479.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB05479.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; BX284606; CAB05479.2; -; Genomic_DNA.
DR RefSeq; NP_510507.2; NM_078106.2.
DR AlphaFoldDB; G5EBV9; -.
DR PaxDb; 6239-F09B12-5; -.
DR EnsemblMetazoa; F09B12.5.1; F09B12.5.1; WBGene00008609.
DR GeneID; 184225; -.
DR KEGG; cel:CELE_F09B12.5; -.
DR AGR; WB:WBGene00008609; -.
DR WormBase; F09B12.5; CE43088; WBGene00008609; -.
DR eggNOG; ENOG502QSXS; Eukaryota.
DR HOGENOM; CLU_710230_0_0_1; -.
DR InParanoid; G5EBV9; -.
DR OMA; RCITNDW; -.
DR OrthoDB; 4337612at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00008609; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF60; PROTEIN CBG07635; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Lipoprotein {ECO:0000313|EMBL:CAB05479.2};
KW Receptor {ECO:0000313|EMBL:CAB05479.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..384
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475985"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 23..35
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 30..48
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 91..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 158..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 384 AA; 41924 MW; 17D31F94684A3277 CRC64;
MNFLLTLISL SLFFPTESSD ETCADGQFRC SNGRCITNDW VCDGARDCSD GSDEEHEACD
RHTNKNSPCF GNQPECEKHG LPRCIPHEWL CDGHPDCDSG EDELNCTSVD WFRQPESLMR
KYQSQLADRS TTTFIFNCAS EDYICKSSGL CLKPNKICDG KFDCDGGDDE KNCTKSNATT
TTISNSLSTT TVVKSTTTLP ISTTTTTTTT ITPKHTNLTT TATTTKKVTT TERAHLENIL
LTIPLKSTTQ SPALTSSSAK PTKPPTTSET SKPTFPSTLP AYVLPMTTTS HPSTHTTTTQ
KVIARTFASQ PHTTSQPKIV VKLLNDSFSN STTDKAKSTE SSASRASVSE LSRYGRNGLV
KPVKFVKGIP IEPVNYHNST FGFE
//
