ID G5EBX1_CAEEL Unreviewed; 1613 AA.
AC G5EBX1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000313|EMBL:CBB16175.1};
GN Name=unc-53 {ECO:0000313|EMBL:CBB16175.1,
GN ECO:0000313|WormBase:F45E10.1g};
GN ORFNames=CELE_F45E10.1 {ECO:0000313|EMBL:CBB16175.1}, F45E10.1
GN {ECO:0000313|WormBase:F45E10.1g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CBB16175.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CBB16175.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CBB16175.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR EMBL; BX284602; CBB16175.1; -; Genomic_DNA.
DR RefSeq; NP_001254272.1; NM_001267343.1.
DR SMR; G5EBX1; -.
DR EnsemblMetazoa; F45E10.1g.1; F45E10.1g.1; WBGene00006788.
DR GeneID; 174693; -.
DR AGR; WB:WBGene00006788; -.
DR WormBase; F45E10.1g; CE44133; WBGene00006788; unc-53.
DR OrthoDB; 4233432at2759; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00006788; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; G5EBX1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0051015; F:actin filament binding; TAS:WormBase.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISS:WormBase.
DR GO; GO:0007411; P:axon guidance; IMP:WormBase.
DR GO; GO:0043057; P:backward locomotion; IMP:WormBase.
DR GO; GO:0048858; P:cell projection morphogenesis; IMP:WormBase.
DR GO; GO:0016204; P:determination of muscle attachment site; IMP:WormBase.
DR GO; GO:0018991; P:egg-laying behavior; IMP:WormBase.
DR GO; GO:0007617; P:mating behavior; IMP:WormBase.
DR GO; GO:0008078; P:mesodermal cell migration; IGI:WormBase.
DR GO; GO:0045773; P:positive regulation of axon extension; IMP:WormBase.
DR GO; GO:0030335; P:positive regulation of cell migration; IGI:WormBase.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:0007165; P:signal transduction; IPI:WormBase.
DR CDD; cd21212; CH_NAV2-like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF28; PROTEIN SICKIE; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 6..115
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 128..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 922..949
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1116..1143
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1613 AA; 176696 MW; 1924D1658FD089FA CRC64;
MTTSNVELIP IYTDWANRHL SKGSLSKSIR DISNDFRDYR LVSQLINVIV PINEFSPAFT
KRLAKITSNL DGLETCLDYL KNLGLDCSKL TKTDIDSGNL GAVLQLLFLL STYKQKLRQL
KKDQKKLEQL PTSIMPPAVS KLPSPRVATS ATASATNPNS NFPQMSTSRL QTPQSRISKI
DSSKIGIKPK TSGLKPPSSS TTSSNNTNSF RPSSRSSGNN NVGSTISTSA KSLESSSTYS
SISNLNRPTS QLQKPSRPQT QLVRVATTTK IGSSKLAAPK AVSTPKLASV KTIGAKQEPD
NSGGGGGGML KLKLFSSKNP SSSSNSPQPT RKAAAVPQQQ TLSKIAAPVK SGLKPPTSKL
GSATSMSKLC TPKVSYRKTD APIISQQDSK RCSKSSEEES GYAGFNSTSP TSSSTEGSLS
MHSTSSKSST SDEKSPSSDD LTLNASIVTA IRQPIAATPV SPNIINKPVE EKPTLAVKGV
KSTAKKDPPP AVPPRDTQPT IGVVSPIMAH KKLTNDPVIS EKPEPEKLQS MSIDTTDVPP
LPPLKSVVPL KMTSIRQPPT YDVLLKQGKI TSPVKSFGYE QSSASEDSIV AHASAQVTPP
TKTSGNHSLE RRMGKNKTSE SSGYTSDAGV AMCAKMREKL KEYDDMTRRA QNGYPDNFED
SSSLSSGISD NNELDDISTD DLSGVDMATV ASKHSDYSHF VRHPTSSSSK PRVPSRSSTS
VDSRSRAEQE NVYKLLSQCR TSQRGAAATS TFGQHSLRSP GYSSYSPHLS VSADKDTMSM
HSQTSRRPSS QKPSYSAAAL NASGMSRSMI LLESLSPRPP RRHQSPADSC IITASPSAPR
RSHSPRGPTA RIPLSLASSP VHVNNNWGSY SARSRGGSST GIYGETFQLH RLSDEKSPAH
SAKSEMGSQL SLASTTAYGS LNEKYEHAIR DMARDLECYK NTVDSLTKKQ ENYGALFDLF
EQKLRKLTQH IDRSNLKPEE AIRFRQDIAH LRDISNHLAS NSAHANEGAG ELLRQPSLES
VASHRSSMSS SSKSSKQEKI SLSSFGKNKK SWIRSSLSKF TKKKNKNYDE AHMPSISGSQ
GTLDNIDVIE LKQELKERDS ALYEVRLDNL DRAREVDVLR ETVNKLKTEN KQLKKEVDKL
TNGPATRASS RASIPVIYDD EHVYDAACSS TSASQSSKRS SGCNSIKVTV NVDIAGEISS
IVNPDKEIIV GYLAMPTSQS CWKDIDVSIL GLFEVYLSRI DVEHQLGIDA RDSILGYQIG
ELRRVIGDST TMITSHPTDI LTSSTTIRMF MHGAAQSRVD SLVLDMLLPK QMILQLVKSI
LTERRLVLAG ATGIGKSKLA KTLAAYVSIR TNQSEDSIVN ISIPENNKEE LLQVERRLEK
ILRSKESCIV ILDNIPKNRI AFVVSVFANV PLQNNEGPFV VCTVNRYQIP ELQIHHNFKM
SVMSNRLEGF ILRYLRRRAV EDEYRLTVQM PSELFKIIDF FPIALQAVNN FIEKTNSVDV
TVGPRACLNC PLTVDGSREW FIRLWNENFI PYLERVARDG KKTFGRCTSF EDPTDIVSEK
WPWFDGENPE NVLKRLQLQD LVPSPANSSR QHFNPLESLI QLHATKHQTI DNI
//
