ID G5EC38_CAEEL Unreviewed; 1045 AA.
AC G5EC38;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Cation transporting ATPase {ECO:0000313|EMBL:CAL99237.1};
DE SubName: Full=Cation-transporting P-type ATPase N-terminal domain-containing protein {ECO:0000313|EMBL:CAN99760.1};
GN Name=catp-1 {ECO:0000313|EMBL:CAN99760.1,
GN ECO:0000313|WormBase:Y105E8A.12b};
GN ORFNames=CELE_Y105E8A.12 {ECO:0000313|EMBL:CAN99760.1}, Y105E8A.12
GN {ECO:0000313|WormBase:Y105E8A.12b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAL99237.1};
RN [1] {ECO:0000313|EMBL:CAN99760.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAN99760.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000313|EMBL:CAN99760.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAN99760.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAL99237.1}
RP NUCLEOTIDE SEQUENCE.
RA Bessereau J.L.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAL99237.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17251264; DOI=10.1242/dev.02790;
RA Ruaud A.-F., Bessereau J.-L.;
RT "The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental
RT timing that acts independently of its predicted pump function.";
RL Development 134:867-879(2007).
RN [5] {ECO:0000313|EMBL:CAN99760.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAN99760.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM419897; CAL99237.1; -; mRNA.
DR EMBL; BX284601; CAN99760.1; -; Genomic_DNA.
DR RefSeq; NP_001122529.1; NM_001129057.2.
DR SMR; G5EC38; -.
DR EnsemblMetazoa; Y105E8A.12b.1; Y105E8A.12b.1; WBGene00013672.
DR GeneID; 173307; -.
DR AGR; WB:WBGene00013672; -.
DR WormBase; Y105E8A.12b; CE41275; WBGene00013672; catp-1.
DR OrthoDB; 2876529at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00013672; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IBA:GO_Central.
DR GO; GO:0040024; P:dauer larval development; IGI:WormBase.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43294:SF4; CATION TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 129..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..145
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 116285 MW; 203680F58E55F145 CRC64;
MTRKPQHPGR NGVVDIHESA GTSICSSSAD NTVTKEKAKR KRAEKEETDH GMTLHDIIKT
SFVEHTLSVD QIRDLYPDSY VFPQCAERSD GLHSDEAKKR LKDGGLNQID RPQEPSLSRF
FLSQFHFKFW ILLLGAAVLS VMTYFIHMAR GFNEPLNLYC AIILIAVVVF MGMLSYWQQA
KAKKVLQENR DMMPVMSYVI RDCEEQEIKA DEIVVGDLVY LRAGYKIPAD MRILQANCLM
IESHDVTGHR MPQEYKSDPV QANVSVFDAC NVAFMGSYCT EGEGIGIVIR TGKFTVLGAL
ANQHHHIPPP SGRLQTELQN FSTFISIVAI SMATVVFFIG CFVARFENVL DHFIVGFVVI
IVANVPQGLP ATVMSQLRII ARRMAQKNIL IKKLELIDEL GAATVICADK SGTLTMNQMV
VTDLWFNSRL VTGQAVDLKH PHLRVMKASM KCPERLEEPL PDILTVMSVC NNGQFEHVRR
GMRRVSTMRA MQKSASEAML SAHMKKKFTI VDTRTGQVSG QAGGVMKEAD QISETEPTEL
GKKRVKPKKN DIFGVPSDVA LIKYVELSAS VEGIRQRYQT VFEIPFNSIR RCQVVVARYL
ASDFPMTSEL VDNPEEGQSR FMIFTKGAPE VILGKCSNYR QGKELKTIDE TYRTECQAAW
EMLGNEGRRV IAFAQKSFNA DDSTKFTGQE YNGDLVFLGM AAIMDPPRPE TAAAIEQCKM
AGVKVFMITG DHPTTATAIA RQIGLIGSST NLNDVEKPQN SWAVVTGDQL KNYKKSDWNL
LLKNHNIVFA RTNTEQKLEI VQEVQRRGET VAVTGGGVDD TPVLAHANVG IAMGQSGSDI
AKQTADIVLL DDNFASIVMG IEEGRLLFDN LRLSLAYTFA HLWPEVFPIM MSFMLGLPHG
LSPLQILSVD LASEMPPAIS LAYEQPENDI MHTPPRSRTA RLLSKSLLVY AYILAGFGIT
IGCIAAYLSV YWYHNIPISD ILFTAEHHWK IGAKNFTTSQ GLTFDPTPVH VRVHTGLPIY
NGHTYSTSTC LGNCSNRRSL PVGFQ
//
