ID HM02_CAEEL Reviewed; 209 AA.
AC G5ECT8;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Homeobox protein ceh-2 {ECO:0000312|WormBase:C27A12.5};
GN Name=ceh-2 {ECO:0000312|WormBase:C27A12.5};
GN ORFNames=C27A12.5 {ECO:0000312|WormBase:C27A12.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAO91835.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC TISSUE=Embryo {ECO:0000303|PubMed:12810585};
RX PubMed=12810585; DOI=10.1242/dev.00551;
RA Aspock G., Ruvkun G., Burglin T.R.;
RT "The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for
RT M3 pharynx motoneuron function.";
RL Development 130:3369-3378(2003).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for activity of the M3 pharyngeal motor neuron.
CC {ECO:0000269|PubMed:12810585}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU000682,
CC ECO:0000269|PubMed:12810585}.
CC -!- TISSUE SPECIFICITY: In the anterior pharynx, expressed in the I3
CC interneuron, the NSM and M3 motor neuron pairs, the three m2 muscle
CC cells and the three e2 epithelial cells (at protein level).
CC {ECO:0000269|PubMed:12810585}.
CC -!- DEVELOPMENTAL STAGE: Earliest expression is detected in late
CC gastrulation (at protein level). Expression is strongest in elongated
CC embryos and early larvae. {ECO:0000269|PubMed:12810585}.
CC -!- DISRUPTION PHENOTYPE: Mutants lacking the homeobox domain are viable
CC and fertile but proliferate slightly more slowly than wild-type due to
CC retarded larval development and reduced brood size. About 20% appear
CC starved as they are shorter, thinner and paler at all stages with
CC severely affected adults bearing only a few eggs. M3 neuron activity is
CC decreased. {ECO:0000269|PubMed:12810585}.
CC -!- MISCELLANEOUS: Can substitute for ems in D.melanogaster ems mutants,
CC partially rescuing the mutant phenotype. {ECO:0000269|PubMed:12810585}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY246428; AAO91835.1; -; mRNA.
DR EMBL; AY246429; AAO91836.1; -; mRNA.
DR EMBL; FO080101; CCD61202.1; -; Genomic_DNA.
DR PIR; E87793; E87793.
DR PIR; S05703; S05703.
DR RefSeq; NP_491746.1; NM_059345.4.
DR AlphaFoldDB; G5ECT8; -.
DR SMR; G5ECT8; -.
DR BioGRID; 56117; 2.
DR IntAct; G5ECT8; 2.
DR STRING; 6239.C27A12.5.1; -.
DR PaxDb; 6239-C27A12-5; -.
DR PeptideAtlas; G5ECT8; -.
DR EnsemblMetazoa; C27A12.5.1; C27A12.5.1; WBGene00000429.
DR GeneID; 191615; -.
DR KEGG; cel:CELE_C27A12.5; -.
DR AGR; WB:WBGene00000429; -.
DR WormBase; C27A12.5; CE20530; WBGene00000429; ceh-2.
DR eggNOG; KOG0843; Eukaryota.
DR GeneTree; ENSGT00940000169446; -.
DR HOGENOM; CLU_1327426_0_0_1; -.
DR InParanoid; G5ECT8; -.
DR OMA; HVQMACS; -.
DR OrthoDB; 903523at2759; -.
DR PhylomeDB; G5ECT8; -.
DR PRO; PR:G5ECT8; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000429; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24339; HOMEOBOX PROTEIN EMX-RELATED; 1.
DR PANTHER; PTHR24339:SF28; HOMEOBOX PROTEIN NOTOCHORD; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..209
FT /note="Homeobox protein ceh-2"
FT /id="PRO_0000430930"
FT DNA_BIND 126..185
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 209 AA; 23414 MW; 3EE28E1C272B2F6D CRC64;
MTLKFSVERL VDSEKESEEA DVEEQNNLKK LEEDEEDDEL CEKSGKNEPL SQTLSYFDVL
LPHVQMACSN PFISGIGASG SGDQNLNTGA GGSVWQHPWL ELLQSTTAAQ FGDVTAGLFL
QPLRKNKRIR TAFSASQLIQ LEKAFEGNHY VVGNERKQLA AKLSLTETQV KVWFQNRRTK
HKRVRLEGSD PNAPMSNDED DEDDKKSVS
//
