ID G5EDN5_CAEEL Unreviewed; 692 AA.
AC G5EDN5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=KQT-1 potassium channel {ECO:0000313|EMBL:AAT77227.1};
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 5 {ECO:0000313|EMBL:CCD65625.1};
GN Name=kqt-1 {ECO:0000313|EMBL:CCD65625.1,
GN ECO:0000313|WormBase:C25B8.1a};
GN ORFNames=C25B8.1 {ECO:0000313|WormBase:C25B8.1a}, CELE_C25B8.1
GN {ECO:0000313|EMBL:CCD65625.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65625.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD65625.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65625.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000313|EMBL:CCD65625.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65625.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAT77227.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15797864; DOI=10.1074/jbc.M502734200;
RA Wei A.D., Butler A., Salkoff L.;
RT "KCNQ-like potassium channels in Caenorhabditis elegans. Conserved
RT properties and modulation.";
RL J. Biol. Chem. 280:21337-21345(2005).
RN [4] {ECO:0000313|EMBL:CCD65625.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65625.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AY572974; AAT77227.1; -; mRNA.
DR EMBL; BX284606; CCD65625.1; -; Genomic_DNA.
DR RefSeq; NP_741820.1; NM_171710.4.
DR SMR; G5EDN5; -.
DR EnsemblMetazoa; C25B8.1a.1; C25B8.1a.1; WBGene00002233.
DR GeneID; 180933; -.
DR AGR; WB:WBGene00002233; -.
DR WormBase; C25B8.1a; CE27086; WBGene00002233; kqt-1.
DR HOGENOM; CLU_011722_8_3_1; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002233; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0005267; F:potassium channel activity; IDA:WormBase.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0007213; P:G protein-coupled acetylcholine receptor signaling pathway; IDA:WormBase.
DR GO; GO:0035556; P:intracellular signal transduction; IDA:WormBase.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; IDA:WormBase.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735:SF9; POTASSIUM VOLTAGE-GATED CHANNEL KQT-LIKE SUBFAMILY, INVERTEBRATE; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000313|EMBL:AAT77227.1};
KW Ion transport {ECO:0000313|EMBL:AAT77227.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:AAT77227.1}.
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..330
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 491..601
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 77487 MW; 6A69D9B21D059BF8 CRC64;
MDEESGSSTD QAAPSDEQQE AGSSSAIGQE SRKTVVFQEP DIGFPSEHDQ LTTLHDSEEG
NRKMSLVGKP LTYKNYRTDQ RFRRMQNKMH NFLERPRGWK AATYHLAVLF MVLMCLALSV
FSTMPDFEVN ATIVLYYLEI VFVIWLATEY ICRVWSAGCR SRYRGISGRI RFATSAYCVI
DIIVILASIT VLCIGATGQV FAASAIRGLR FFQILRMLRI DRRAGTWKLL GSVVWAHRQE
LLTTVYIGFL GLIFSSFLVY LCEKNTNDKY QTFADALWWG VITLSTVGYG DKTPETWPGK
IIAAFCALLG ISFFALPAGI LGSGFALKVQ QHQRQKHLIR RRVPAAKLIQ CLWRHYSAAP
ESTSLATWKI HLARELPPIV KLTPNGSNNA TGLINRLRQS TKRTPNLNNQ NLAVNSQATS
KNLSVPRVHD TISLVSTSDI SEIEQLGALG FSLGWKSKSK YGGSKKATDD SVLQSRMLAP
SNAHLDEEEA VGYQPQTIEE FTPALKNCVR AIRRIQLLVA RKKFKEALKP YDVKDVIEQY
SAGHVDLQSR VKTVQAKLDF ICGKNIEKIE PKISMFTRIA TLETTVGKMD KKLDLMVEML
MGRQASQRVF SQNTSPRGEF SEPTSARQDL TRSRRSMVST DMEMYTARSH SPGYHGDARP
IIAQIDADDD DEDENVFDDS TPLNNGPGTS SC
//
