ID G5EDU4_CAEEL Unreviewed; 909 AA.
AC G5EDU4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=EOR-1 {ECO:0000313|EMBL:AAM74151.1};
DE SubName: Full=Zinc finger protein {ECO:0000313|EMBL:CCD72242.1};
GN Name=eor-1 {ECO:0000313|EMBL:CCD72242.1,
GN ECO:0000313|WormBase:R11E3.6a};
GN ORFNames=CELE_R11E3.6 {ECO:0000313|EMBL:CCD72242.1}, R11E3.6
GN {ECO:0000313|WormBase:R11E3.6a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72242.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD72242.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72242.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000313|EMBL:AAM74222.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12130541; DOI=10.1101/gad.998402;
RA Howard R.M., Sundaram M.V.;
RT "C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling
RT and function redundantly with LIN-25 and the SUR-2 Mediator component.";
RL Genes Dev. 16:1815-1827(2002).
RN [3] {ECO:0000313|EMBL:CCD72242.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72242.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAM74151.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15355793; DOI=10.1016/j.ydbio.2004.06.022;
RA Hoeppner D.J., Spector M.S., Ratliff T.M., Kinchen J.M., Granat S.,
RA Lin S.C., Bhusri S.S., Conradt B., Herman M.A., Hengartner M.O.;
RT "eor-1 and eor-2 are required for cell-specific apoptotic death in C.
RT elegans.";
RL Dev. Biol. 274:125-138(2004).
RN [5] {ECO:0000313|EMBL:CCD72242.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72242.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AF502568; AAM74151.1; -; mRNA.
DR EMBL; AF519108; AAM74222.1; -; mRNA.
DR EMBL; BX284604; CCD72242.1; -; Genomic_DNA.
DR PIR; T33749; T33749.
DR RefSeq; NP_500645.1; NM_068244.5.
DR SMR; G5EDU4; -.
DR IntAct; G5EDU4; 59.
DR MINT; G5EDU4; -.
DR STRING; 6239.R11E3.6a.1; -.
DR PaxDb; 6239-R11E3-6a; -.
DR EnsemblMetazoa; R11E3.6a.1; R11E3.6a.1; WBGene00001324.
DR AGR; WB:WBGene00001324; -.
DR WormBase; R11E3.6a; CE19548; WBGene00001324; eor-1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_014896_0_0_1; -.
DR OMA; INLKRHV; -.
DR OrthoDB; 2874000at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00001324; Expressed in embryo and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IMP:WormBase.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:0040011; P:locomotion; IMP:WormBase.
DR GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
DR GO; GO:0051402; P:neuron apoptotic process; IMP:WormBase.
DR GO; GO:0001764; P:neuron migration; IMP:WormBase.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
DR GO; GO:0012501; P:programmed cell death; IMP:UniProtKB.
DR GO; GO:0007265; P:Ras protein signal transduction; IGI:WormBase.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IMP:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IGI:WormBase.
DR CDD; cd18186; BTB_POZ_ZBTB_KLHL-like; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24388:SF67; EOR-1; 1.
DR PANTHER; PTHR24388; ZINC FINGER PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Proteomics identification {ECO:0007829|EPD:G5EDU4};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 42..107
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 509..532
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 539..566
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 567..594
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 594..623
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 624..651
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 652..680
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 300..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 909 AA; 103916 MW; 72A869D747B733F6 CRC64;
MTLVASSENT GLCPMTFDDS SGQTSHMLFQ RLQYQRKTGR FCDVEIVVQN KSFAAHRNIL
AAHSPYFDAI FKYCKITKEQ LTINSKSPQV FELFLNYMYS GTVIIDRSSV SELLRFANNF
LIVKLKVYCA AYLDRYLDAA NCLSIRTLAQ RYNLPGLVKS ATDYFDSNLN RCLLESRDII
GYTYTQLTRL IGDPKYVDCI TSDTYLKLIV RWVGEEVSKR EEIFRLLLES CEFREVSADT
LEFLLDYSPL LSKSQKSRFL LLHVMETNNM LMEKYSTQLS SLRQKIVDLP ILHDPSQFED
DIYDSSDSEE DPDDYIADGH PTSAQVVEYG NDVNNRLKMK IAFQPGNEKK RLKRPKGMKK
HHLHPIPPIN ATENESIPWI DEDEIDGVYA TCSLEGCHTY GPVDNLDPDD CEDEEDQPDE
NGPSTCIFCG LRTANEELLE KHKARHHNRN TYYMCHLCEF ETNWSKQFYL HCAEHWTEIP
YRCETCPFTS NEIQEFLTHR LQHTDERFFK CGECAWKGRT RSQLFAHERM HSVLDDRSLH
CEECGRGFQQ HSTLDHHVAS HNDPRPYICE DCGFATKTAD HLSLHRRQHT GDNFSCHIAG
CDYSSTKKSQ LAAHLRTHMA VRAHLCKICG RGFIEKSHLV RHERIHLEEK PFKCDQCEYA
SSRRDKLKEH IIKHHNSEVL TFQKTQRRKY KRQRMLAAAS NIVNNPDALF RPITSDDAVS
NWQATNDFST YSPNPNDYGG PSTYGNPSSP QRAFSVVHPS QHQHHAQSPG CMSMMNVPLR
DNHHQMQRQD SPGDSVGGGQ GGGGGGGPEG SDNTHGVLMT PNLVMRSPHN RSAVQPQFNN
LSTNSDPQQQ QQQQQLRPFS LPTYGQMDLA QAAQLQQLQQ QLQAAGLPPT GTPNNQDNSN
NAWNPWNVQ
//
