ID G5EEJ2_CAEEL Unreviewed; 259 AA.
AC G5EEJ2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Cyclin-dependent kinase inhibitor {ECO:0000313|EMBL:AAF13869.1, ECO:0000313|EMBL:CAD45597.1};
GN Name=cki-2 {ECO:0000313|EMBL:CAD45597.1,
GN ECO:0000313|WormBase:T05A6.2b};
GN ORFNames=CELE_T05A6.2 {ECO:0000313|EMBL:CAD45597.1}, T05A6.2
GN {ECO:0000313|WormBase:T05A6.2b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:AAF13869.1};
RN [1] {ECO:0000313|EMBL:CAD45597.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD45597.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000313|EMBL:AAF13869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=N2 Bristol {ECO:0000313|EMBL:AAF13869.1};
RX PubMed=10587644; DOI=10.1038/70272;
RA Feng H., Zhong W., Punkosdy G., Gu S., Zhou L., Seabolt E.K., Kipreos E.T.;
RT "CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome
RT condensation in Caenorhabditis elegans.";
RL Nat. Cell Biol. 1:486-492(1999).
RN [3] {ECO:0000313|EMBL:CAD45597.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD45597.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAD45597.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD45597.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDI family. {ECO:0000256|ARBA:ARBA00006726}.
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DR EMBL; AF179359; AAF13869.1; -; mRNA.
DR EMBL; BX284602; CAD45597.1; -; Genomic_DNA.
DR RefSeq; NP_001022309.1; NM_001027138.4.
DR SMR; G5EEJ2; -.
DR STRING; 6239.T05A6.2b.1; -.
DR PaxDb; 6239-T05A6-2b; -.
DR EnsemblMetazoa; T05A6.2b.1; T05A6.2b.1; WBGene00000517.
DR EnsemblMetazoa; T05A6.2b.2; T05A6.2b.2; WBGene00000517.
DR GeneID; 174261; -.
DR AGR; WB:WBGene00000517; -.
DR WormBase; T05A6.2b; CE31824; WBGene00000517; cki-2.
DR eggNOG; KOG4743; Eukaryota.
DR HOGENOM; CLU_1086767_0_0_1; -.
DR OrthoDB; 2900553at2759; -.
DR Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CEL-198323; AKT phosphorylates targets in the cytosol.
DR Reactome; R-CEL-2559586; DNA Damage/Telomere Stress Induced Senescence.
DR Reactome; R-CEL-6804116; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
DR Reactome; R-CEL-69202; Cyclin E associated events during G1/S transition.
DR Reactome; R-CEL-69231; Cyclin D associated events in G1.
DR Reactome; R-CEL-69563; p53-Dependent G1 DNA Damage Response.
DR Reactome; R-CEL-69656; Cyclin A:Cdk2-associated events at S phase entry.
DR Reactome; R-CEL-8849470; PTK6 Regulates Cell Cycle.
DR Reactome; R-CEL-9634638; Estrogen-dependent nuclear events downstream of ESR-membrane signaling.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000517; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISS:WormBase.
DR GO; GO:0008406; P:gonad development; IGI:UniProtKB.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IMP:WormBase.
DR GO; GO:1902806; P:regulation of cell cycle G1/S phase transition; IGI:UniProtKB.
DR GO; GO:0051302; P:regulation of cell division; IGI:UniProtKB.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IGI:UniProtKB.
DR Gene3D; 4.10.365.10; p27; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR PANTHER; PTHR10265; CYCLIN-DEPENDENT KINASE INHIBITOR 1; 1.
DR PANTHER; PTHR10265:SF45; DACAPO; 1.
DR Pfam; PF02234; CDI; 1.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Proteomics identification {ECO:0007829|EPD:G5EEJ2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 16..67
FT /note="Cyclin-dependent kinase inhibitor"
FT /evidence="ECO:0000259|Pfam:PF02234"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 259 AA; 28651 MW; 904F9814A9897EA8 CRC64;
MAATTAGDGK RKAARCLFGK PDPEEQVSRQ LNSSLEEMYK KDSRKFNFDF SGGVPIVGSR
GDYEFESISA SEVPSFYREK IVRPRKIIAR RNSTPVSDTV EMPSESPPVV ESNETPLLIA
STSTEVTVYE KPVTRSSAAK QSIEQQETYN LKQTKLTNYM PVRKRRSETC LVTAAVSMSR
SVSIDSSMES CKEKRGSKIV HNNKGAPKRP LRFVASNVPK SAQSSTSDTV LVSSPRSPPA
KKMTTSTRRS RRPIEAGDF
//
