ID G5EF89_CAEEL Unreviewed; 1138 AA.
AC G5EF89;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Fibronectin type-III domain-containing protein {ECO:0000313|EMBL:CAD21701.2};
GN Name=cle-1 {ECO:0000313|EMBL:CAD21701.2,
GN ECO:0000313|WormBase:C36B1.1a};
GN ORFNames=C36B1.1 {ECO:0000313|WormBase:C36B1.1a}, CELE_C36B1.1
GN {ECO:0000313|EMBL:CAD21701.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD21701.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD21701.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD21701.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284601; CAD21701.2; -; Genomic_DNA.
DR RefSeq; NP_740896.2; NM_170904.2.
DR AlphaFoldDB; G5EF89; -.
DR SMR; G5EF89; -.
DR EPD; G5EF89; -.
DR EnsemblMetazoa; C36B1.1a.1; C36B1.1a.1; WBGene00000527.
DR GeneID; 172678; -.
DR KEGG; cel:CELE_C36B1.1; -.
DR AGR; WB:WBGene00000527; -.
DR WormBase; C36B1.1a; CE36988; WBGene00000527; cle-1.
DR OrthoDB; 5363002at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000527; Expressed in larva and 4 other cell types or tissues.
DR ExpressionAtlas; G5EF89; baseline and differential.
DR GO; GO:0005604; C:basement membrane; IDA:WormBase.
DR GO; GO:0030054; C:cell junction; IDA:WormBase.
DR GO; GO:0005587; C:collagen type IV trimer; IBA:GO_Central.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:WormBase.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR GO; GO:0040039; P:inductive cell migration; IMP:WormBase.
DR GO; GO:0001764; P:neuron migration; IMP:WormBase.
DR GO; GO:0035418; P:protein localization to synapse; IMP:WormBase.
DR GO; GO:0050808; P:synapse organization; IMP:WormBase.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IMP:WormBase.
DR CDD; cd00247; Endostatin-like; 1.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1108; ENDOSTATIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 2.
PE 1: Evidence at protein level;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Proteomics identification {ECO:0007829|EPD:G5EF89,
KW ECO:0007829|PeptideAtlas:G5EF89};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1138
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003476142"
FT DOMAIN 35..126
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 136..237
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 152..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..638
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 124178 MW; B2C69581A4BCFB80 CRC64;
MIETGSQYLL FLLFICSLFN SGSTALQHED RVPNAPQNVR IKTQSTSATL WWDAPPDPTV
LIRGYTVEYG EGSISQRILI EGPDSTSFTV TRLSPNTNYV FAVSAYNEAE GEDGTKVMVA
AKTRPSEGSQ TEKLWPPTSV RARIDEKSAA GSAFVSWDDP NPESSSENSI DSTQKQYVIN
YGIYESDTQQ KVRSNAKAVR LTGLIPGKEY EVAVKVVAGD GRESPWSIRD LFLVPETKTV
SKFDWFCRLN DTEMCSIHSS PHWKLCSEKH DTYTQRDAGA CPRVQYPSSP AHLTTPAINL
PDAQRLCLYF RFALLNFHPG QMKVEIFRDG DMANKQIVWK TRMANVRTHV VQNVYVPFSQ
QIKPFKVSVS LKWDGQPMPR VIVHEMDVLS GGCSERSTDS ETEVDLLAPV KASLNADARV
FRAKGIESLP AIGLQRGVEI AVPYRLYLPR NFFKQFSLLA TIKPMDKRGG YLFAAVNAYD
SAVDIGLLIE PAGTKQTNIS LIVRSVAIVS FLVEDFSQQW TQFALEVVDQ TVTFYFKCRR
FASRQVTSLP DFSFDEAEKL YIASAGPIID NGFEGAIQEL KLIDDATQGS RQCDEQWGAE
GSGTPEEFKK TQESSELQKI SDFPPTPAPP PPYPTPQLAP HDLRSYEQQA ATTPFQGAPP
SNQCTQVCRG EPGPQGPSGN DGIPGSHGAP GHQGERGADG APGLHGSRGD QGLPGPPGMP
GLAGPPGPPG SGTGHGSGAD GPQGPPGLPG APGRDGTSGV EGQRGPQGPP GPKGDDGVSM
ESLTDDDIER IARRVASIQK ESNEPMRGDL PEYNSKVHSF TTKGEKGERG APGAPGAPAP
PAYGTLTTGT AVNVHATTVE LFASARSTSV GQLAFATSSQ QLFIRVTNGW KEIQLTHFHP
FVETRHSTQN SRQNDASHAG RSRTGSAAAP WYPKANLDEP QRDAGVHNKD RVIHMIALSQ
PFSGNLHGLR GADLQCYREA RAAGYTTTFR AMLSSNVQDL VRIVHSVDFD TTVVNVAGHH
LFPSWRSFVN GAQMNPHAKL FSFDRHDVLN DSRWPDKRVW HGSKDGGIRA EQYCDGWRRA
DSSLTSLAGH ISSNTSIFQS SGSEKCENKL VVLCVENMSK YHGDRILRLH RITSDFKK
//
