ID G5EFS1_CAEEL Unreviewed; 597 AA.
AC G5EFS1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Death domain-containing protein {ECO:0000313|EMBL:CAB62796.1};
DE SubName: Full=IKB-1 {ECO:0000313|EMBL:AAK37547.1};
GN Name=ikb-1 {ECO:0000313|EMBL:CAB62796.1,
GN ECO:0000313|WormBase:C04F12.3};
GN ORFNames=C04F12.3 {ECO:0000313|WormBase:C04F12.3}, CELE_C04F12.3
GN {ECO:0000313|EMBL:CAB62796.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB62796.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB62796.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB62796.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000313|EMBL:AAK37547.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11516642; DOI=10.1016/S0960-9822(01)00241-X;
RA Pujol N., Link E.M., Liu L.X., Kurz C.L., Alloing G., Tan M., Ray K.P.,
RA Solari R., Johnson C.D., Ewbank J.J.;
RT "A reverse genetic analysis of components of the Toll signaling pathway in
RT Caenorhabditis elegans.";
RL Curr. Biol. 11:809-821(2001).
RN [3] {ECO:0000313|EMBL:CAB62796.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB62796.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAB62796.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB62796.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC G5EFS1; Q9TZK8: meg-4; NbExp=3; IntAct=EBI-314119, EBI-314126;
CC G5EFS1; Q03601: nhl-1; NbExp=5; IntAct=EBI-314119, EBI-314158;
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DR EMBL; AF348169; AAK37547.1; -; mRNA.
DR EMBL; BX284601; CAB62796.1; -; Genomic_DNA.
DR RefSeq; NP_492575.1; NM_060174.5.
DR SMR; G5EFS1; -.
DR IntAct; G5EFS1; 9.
DR MINT; G5EFS1; -.
DR STRING; 6239.C04F12.3.1; -.
DR PaxDb; 6239-C04F12-3; -.
DR EnsemblMetazoa; C04F12.3.1; C04F12.3.1; WBGene00002069.
DR GeneID; 172817; -.
DR KEGG; cel:CELE_C04F12.3; -.
DR AGR; WB:WBGene00002069; -.
DR WormBase; C04F12.3; CE19676; WBGene00002069; ikb-1.
DR eggNOG; KOG0504; Eukaryota.
DR HOGENOM; CLU_457284_0_0_1; -.
DR OMA; CLADSED; -.
DR OrthoDB; 5406967at2759; -.
DR Reactome; R-CEL-8951664; Neddylation.
DR Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002069; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; HDA:WormBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:WormBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08310; Death_NFkB-like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Proteomics identification {ECO:0007829|EPD:G5EFS1,
KW ECO:0007829|PeptideAtlas:G5EFS1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT REPEAT 212..244
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 282..314
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 316..348
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 349..381
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 502..595
FT /note="Death"
FT /evidence="ECO:0000259|SMART:SM00005"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 66422 MW; CD271E6B4CF25A35 CRC64;
MSKADENDAN LTENGVHKSR SDSEINSHTS SIHKSSSQHR RLFIDDISTI EASAGDRVWA
TCSGAGDATE LITIHFLGDQ FEESAIDVVR KHSLVMFTVP SLKVDSELEV ELRFSTSNDN
VTTISFKYLP RKIQRSHTQE ISLFDNLLEF ATNGDTISLL QPFVAQISKQ DIEGNTVFHV
AAKNGQSFSL KLLLSVIPPD IKNEVINVQN THGLTALHVA IRTGDPDAVH YLMNHGAKID
ISDNHGSTAL HYLGDAYNES IFKEILEPSR GQRFDVNQLN SEGFAPIHVA VRRLKLSLIE
MLIEAGALID FLDTEKKRNA LMHAIEMNDF ETIQLLVERG SGTNIEDESG ETALSLAVKN
VNYPVIGLLL DNGADPNRQN SKGICLADSE DSVIQNIING DRPELPKKEA FGVPNDLAIS
RSPLFGRSHP DQAPGEESGR HRVVKRSREE ILNDAQTLLA ETDSMAPRVS RISTSESEDE
QQPGPSTSSG TRRRRSEWDR NPKLSDSVCN LDYLTRIRVA KIFDDQCKWQ RLAQQLNCDH
MVELISICSS GDDSSPTMIL LDQFEQLEDS SISRLRDAMN QMAEDDAVKL IDSRYVY
//
