ID G5EG28_CAEEL Unreviewed; 497 AA.
AC G5EG28;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
GN Name=eif-2bdelta {ECO:0000313|WormBase:F11A3.2b};
GN Synonyms=eif-2Bdelta {ECO:0000313|EMBL:CAI91168.1};
GN ORFNames=CELE_F11A3.2 {ECO:0000313|EMBL:CAI91168.1}, F11A3.2
GN {ECO:0000313|WormBase:F11A3.2b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAI91168.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAI91168.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAI91168.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; BX284605; CAI91168.1; -; Genomic_DNA.
DR RefSeq; NP_001023785.1; NM_001028614.3.
DR AlphaFoldDB; G5EG28; -.
DR SMR; G5EG28; -.
DR EPD; G5EG28; -.
DR PeptideAtlas; G5EG28; -.
DR EnsemblMetazoa; F11A3.2b.1; F11A3.2b.1; WBGene00008670.
DR GeneID; 179331; -.
DR AGR; WB:WBGene00008670; -.
DR WormBase; F11A3.2b; CE38501; WBGene00008670; eif-2Bdelta.
DR GeneTree; ENSGT00550000075009; -.
DR HOGENOM; CLU_039342_0_0_1; -.
DR OrthoDB; 2883689at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00008670; Expressed in adult organism and 4 other cell types or tissues.
DR ExpressionAtlas; G5EG28; baseline and differential.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0019915; P:lipid storage; IMP:WormBase.
DR GO; GO:0009408; P:response to heat; IMP:WormBase.
DR GO; GO:0006979; P:response to oxidative stress; IMP:WormBase.
DR GO; GO:0006412; P:translation; IMP:WormBase.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:CAI91168.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Proteomics identification {ECO:0007829|EPD:G5EG28,
KW ECO:0007829|PeptideAtlas:G5EG28};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 54510 MW; D9C85E36D2CC6246 CRC64;
MILGVKSENN QQVVPPTTAE EPAQGEDKNQ YHKDVTAEDK KARKAAKAAE KKARAEKSVA
NKAAAAAGST QNQGQKKEKP PKEHSAVPSE STTKLIEENA QLTKTTEQLA AKMETLVIED
VKINGSLKPA IKKSTGVEKN VRHVHNVIMP SVVTFDLPKN QTKTLPSASD SDEAVASEIE
STAIAQLDDA TSFVHIHPAF LTLMAKAELE KIPDVETVCI QFIAAFKEFL RDWTVEREKN
NINASTFGHD LDLAIRPQLA HMTQNGHWPL PFALGNTVRL LKRTIKRLEE STNMKCEEEL
QVYLEDTLAI NFCHAYKAIS QLLVRKIQQF KKVVVFDWCP VVNHVLLEAK QQIPDMQLSV
IDANSNGRGT RHVKSFVDQG YNVKYVTMKG ASWASLASGV LILGCSAIFA NGAVAARKGA
LAVVLCANHY NIPVIVVAEH FKFIDKGQVY QRVALLGRQN IECIQSDLVT AVVTDLRILG
PTSAPAVLKA KALTDMA
//
