ID G5EGG8_CAEEL Unreviewed; 357 AA.
AC G5EGG8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=DNA repair protein RAD51 homolog {ECO:0000256|RuleBase:RU364139};
GN Name=rad-51 {ECO:0000313|EMBL:CAE47473.1,
GN ECO:0000313|WormBase:Y43C5A.6b};
GN Synonyms=rad51 {ECO:0000313|EMBL:AAD10194.1};
GN ORFNames=CELE_Y43C5A.6 {ECO:0000313|EMBL:CAE47473.1}, Y43C5A.6
GN {ECO:0000313|WormBase:Y43C5A.6b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:BAA24982.1};
RN [1] {ECO:0000313|EMBL:BAA24982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10048487; DOI=10.1093/dnares/5.6.373;
RA Takanami T., Sato S., Ishihara T., Katsura I., Takahashi H.,
RA Higashitani A.;
RT "Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1
RT involved in meiotic recombination.";
RL DNA Res. 5:373-377(1998).
RN [2] {ECO:0000313|EMBL:AAD10194.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB1392 {ECO:0000313|EMBL:AAD10194.1};
RX PubMed=9862483; DOI=10.1007/s004380050897;
RA Rinaldo C., Ederle S., Rocco V., La Volpe A.;
RT "The Caenorhabditis elegans RAD51 homolog is transcribed into two
RT alternative mRNAs potentially encoding proteins of different sizes.";
RL Mol. Gen. Genet. 260:289-294(1998).
RN [3] {ECO:0000313|EMBL:CAE47473.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAE47473.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4] {ECO:0000313|EMBL:CAE47473.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAE47473.1};
RA Sulson J.E., Waterston R.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:CAE47473.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAE47473.1};
RG WormBase Consortium;
RA WormBase;
RL Submitted (AUG-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds to single and double-stranded DNA and exhibits DNA-
CC dependent ATPase activity. Underwinds duplex DNA.
CC {ECO:0000256|RuleBase:RU364139}.
CC -!- INTERACTION:
CC G5EGG8; G5EG86: brc-2; NbExp=3; IntAct=EBI-2315986, EBI-325989;
CC G5EGG8; G5EGG8: rad-51; NbExp=2; IntAct=EBI-2315986, EBI-2315986;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364139}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
CC {ECO:0000256|ARBA:ARBA00007095, ECO:0000256|RuleBase:RU364139}.
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DR EMBL; AF061201; AAD10194.1; -; mRNA.
DR EMBL; AB011382; BAA24982.1; -; mRNA.
DR EMBL; BX284604; CAE47473.1; -; Genomic_DNA.
DR PIR; T37305; T37305.
DR RefSeq; NP_001023466.1; NM_001028295.2.
DR SMR; G5EGG8; -.
DR DIP; DIP-60921N; -.
DR IntAct; G5EGG8; 2.
DR EnsemblMetazoa; Y43C5A.6b.1; Y43C5A.6b.1; WBGene00004297.
DR AGR; WB:WBGene00004297; -.
DR WormBase; Y43C5A.6b; CE25285; WBGene00004297; rad-51.
DR HOGENOM; CLU_041732_0_0_1; -.
DR OrthoDB; 5477610at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004297; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:WormBase.
DR GO; GO:0043073; C:germ cell nucleus; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IDA:WormBase.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IDA:WormBase.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0017151; F:DEAD/H-box RNA helicase binding; IPI:WormBase.
DR GO; GO:0000150; F:DNA strand exchange activity; IDA:WormBase.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:WormBase.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IMP:WormBase.
DR GO; GO:0000730; P:DNA recombinase assembly; IBA:GO_Central.
DR GO; GO:0042148; P:DNA strand invasion; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IGI:WormBase.
DR GO; GO:0010032; P:meiotic chromosome condensation; IMP:WormBase.
DR GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:WormBase.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR CDD; cd19513; Rad51; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011941; DNA_recomb/repair_Rad51.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR NCBIfam; TIGR02239; recomb_RAD51; 1.
DR PANTHER; PTHR22942:SF39; DNA REPAIR PROTEIN RAD51 HOMOLOG 1; 1.
DR PANTHER; PTHR22942; RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003422};
KW DNA damage {ECO:0000256|RuleBase:RU364139};
KW DNA recombination {ECO:0000256|RuleBase:RU364139};
KW DNA repair {ECO:0000256|RuleBase:RU364139};
KW DNA-binding {ECO:0000256|RuleBase:RU364139};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003422};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364139};
KW Proteomics identification {ECO:0007829|EPD:G5EGG8,
KW ECO:0007829|PeptideAtlas:G5EGG8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 114..285
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
FT DOMAIN 293..356
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 39194 MW; ECED8C7021204BED CRC64;
MSAQASRQKK SDQEQRAADQ ALLNAAIEDN AMEQDENFTV IDKLESSGIS SGDISKLKEA
GYYTYESLAF TTRRELRNVK GISDQKAEKI MKEAMKFVQM GFTTGAEVHV KRSQLVQIRT
GSASLDRLLG GGIETGSITE VYGEYRTGKT QLCHSLAVLC QLPIDMGGGE GKCMYIDTNA
TFRPERIIAI AQRYNMDSAH VLENIAVARA YNSEHLMALI IRAGAMMSES RYAVVIVDCA
TAHFRNEYTG RGDLAERQMK LSAFLKCLAK LADEYGVAVI ITNQVVAQVD GGASMFQADA
KKPIGGHIIA HMSTTRLYLR KGKGENRVAK MVQSPNLPEA EATYSITNHG IEDARED
//
