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Database: UniProt
Entry: G5GN10_9FIRM
LinkDB: G5GN10_9FIRM
Original site: G5GN10_9FIRM 
ID   G5GN10_9FIRM            Unreviewed;       287 AA.
AC   G5GN10;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   10-APR-2019, entry version 30.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=HMPREF9334_00641 {ECO:0000313|EMBL:EHG21671.1};
OS   Selenomonas infelix ATCC 43532.
OC   Bacteria; Firmicutes; Negativicutes; Selenomonadales;
OC   Selenomonadaceae; Selenomonas.
OX   NCBI_TaxID=679201 {ECO:0000313|EMBL:EHG21671.1, ECO:0000313|Proteomes:UP000004129};
RN   [1] {ECO:0000313|EMBL:EHG21671.1, ECO:0000313|Proteomes:UP000004129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43532 {ECO:0000313|EMBL:EHG21671.1,
RC   ECO:0000313|Proteomes:UP000004129};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Blanton J.M.,
RA   Baranova O.V., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA   Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Selenomonas infelix ATCC 43532.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EHG21671.1}.
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DR   EMBL; ACZM01000005; EHG21671.1; -; Genomic_DNA.
DR   STRING; 679201.HMPREF9334_00641; -.
DR   EnsemblBacteria; EHG21671; EHG21671; HMPREF9334_00641.
DR   PATRIC; fig|679201.3.peg.645; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000004129; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004129};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        6    187       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      203    278       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        180    180       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   287 AA;  31340 MW;  965A7FD4AB80802A CRC64;
     MCVRQKMGVL GPVGTHSEAA ARYLMEWQSL DREIVCFGDI SECLHAVEMG VVDAAFVPVE
     NSLEGAIAVT LDALARSDTL RVRREVIWPV HNYLMARAKD AEIRVVYSHA QPLAQCRDFL
     LRHCPQAELI KTASTARAAE IVGASLADAG AAAICTRRAG ALNGLVEIAG RIEDRGSNCT
     RFFEVVRDGM LPPPAEEPDT VLLVCQIDGT RPGALYDVLG EFAHRAVNLT RIESRPARTE
     LGAYMFFFDL DAHSDADAIR DAIDAVAEKS VWLKVLGVFP VHTARNE
//
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